PMID- 16627455
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20220311
IS  - 1099-5129 (Print)
IS  - 1099-5129 (Linking)
VI  - 8
IP  - 4
DP  - 2006 Apr
TI  - Post-operative use of heparin increases morbidity of pacemaker implantation.
PG  - 283-7
AB  - AIMS: The objective of this study is to characterize the incidence of 
      peri-operative severe adverse events (AEs) related to the post-operative use of 
      heparin in patients undergoing pacemaker surgery. METHODS AND RESULTS: We 
      retrospectively compared the outcome of 38 patients with mechanical valves (MVs) 
      and 76 patients with atrial fibrillation (AF) with control cases matched for 
      gender, age, and surgical details. Heparin was systematically used 
      post-operatively in MV patients, but left to clinical judgment in AF patients. 
      The relative risk for severe haemorrhagic AEs was 11 (CI 1.5-81.1, P < 0.01) in 
      the MV group when compared with matched controls and 8 (CI 1.0-62.5, P < 0.05) in 
      the AF group. Overall, the relative risk of heparin use in the post-operative 
      period was 14 (CI 1.88-104, P = 0.0006) and the post-operative stay was prolonged 
      from 7 days in this group when compared with control cases (P < 0.0001).The 
      variables associated with haemorrhage were the delay to restart heparin after 
      surgery and the presence of an MV. CONCLUSION: Post-operative use of heparin 
      increases morbidity of pacemaker implantation. A different approach to management 
      of these patients is possible.
FAU - Marquie, C
AU  - Marquie C
AD  - CHRU, Cardiologie A, Cardiologic Hospital, bl du Pr, Lille 59037, France. 
      c-marquie@chru-lille.fr
FAU - De Geeter, G
AU  - De Geeter G
FAU - Klug, D
AU  - Klug D
FAU - Kouakam, C
AU  - Kouakam C
FAU - Brigadeau, F
AU  - Brigadeau F
FAU - Jabourek, O
AU  - Jabourek O
FAU - Trillot, N
AU  - Trillot N
FAU - Lacroix, D
AU  - Lacroix D
FAU - Kacet, S
AU  - Kacet S
LA  - eng
PT  - Journal Article
DEP - 20060316
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - Anticoagulants/administration & dosage/adverse effects
MH  - Atrial Fibrillation/*therapy
MH  - Case-Control Studies
MH  - Female
MH  - *Heart Valve Prosthesis
MH  - Hemorrhage/epidemiology/*etiology
MH  - Heparin/administration & dosage/*adverse effects
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - *Pacemaker, Artificial
MH  - Postoperative Period
MH  - Retrospective Studies
EDAT- 2006/04/22 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/04/22 09:00
PHST- 2006/04/22 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/04/22 09:00 [entrez]
AID - eul011 [pii]
AID - 10.1093/europace/eul011 [doi]
PST - ppublish
SO  - Europace. 2006 Apr;8(4):283-7. doi: 10.1093/europace/eul011. Epub 2006 Mar 16.