PMID- 16627958
OWN - NLM
STAT- MEDLINE
DCOM- 20060720
LR  - 20190710
IS  - 1420-9519 (Print)
IS  - 1420-9519 (Linking)
VI  - 13
DP  - 2006
TI  - Adult stem cell theory of the multi-stage, multi-mechanism theory of 
      carcinogenesis: role of inflammation on the promotion of initiated stem cells.
PG  - 45-65
LID - 10.1159/000092965 [doi]
AB  - Inflammation, induced by microbial agents, radiation, endogenous or exogenous 
      chemicals, has been associated with chronic diseases, including cancer. Since 
      carcinogenesis has been characterized as consisting of the 'initiation', 
      'promotion' and 'progression' phases, the inflammatory process could affect any 
      or all three phases. The stem cell theory of carcinogenesis has been given a 
      revival, in that isolated human adult stem cells have been isolated and shown to 
      be 'targets' for neoplastic transformation. Oct4, a transcription factor, has 
      been associated with adult stem cells, as well as their immortalized and 
      tumorigenic derivatives, but not with the normal differentiated daughters. These 
      data are consistent with the stem cell theory of carcinogenesis. In addition, Gap 
      Junctional Intercellular Communication (GJIC) seems to play a major role in cell 
      growth. Inhibition of GJIC by non-genotoxic chemicals or various oncogenes seems 
      to be the mechanism for the tumor promotion and progression phases of 
      carcinogenesis. Many of the toxins, synthetic non-genotoxicants, and endogenous 
      inflammatory factors have been shown to inhibit GJIC and act as tumor promoters. 
      The inhibition of GJIC might be the mechanism by which the inflammatory process 
      affects cancer and that to intervene during tumor promotion with 
      anti-inflammatory factors might be the most efficacious anti-cancer strategy.
FAU - Trosko, James E
AU  - Trosko JE
AD  - Department of Pediatrics and Human Development, National Food Safety Toxicology 
      Center, College of Human Medicine, Michigan State University, East Lansing, 
      Mich., USA.
FAU - Tai, Mei-Hui
AU  - Tai MH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Contrib Microbiol
JT  - Contributions to microbiology
JID - 9815689
SB  - IM
MH  - Animals
MH  - Cell Transformation, Neoplastic/*pathology
MH  - Humans
MH  - Inflammation/*pathology
MH  - Neoplasms/*etiology/pathology
MH  - Neoplastic Stem Cells/*pathology
MH  - Stem Cells/*pathology
RF  - 132
EDAT- 2006/04/22 09:00
MHDA- 2006/07/21 09:00
CRDT- 2006/04/22 09:00
PHST- 2006/04/22 09:00 [pubmed]
PHST- 2006/07/21 09:00 [medline]
PHST- 2006/04/22 09:00 [entrez]
AID - 000092965 [pii]
AID - 10.1159/000092965 [doi]
PST - ppublish
SO  - Contrib Microbiol. 2006;13:45-65. doi: 10.1159/000092965.