PMID- 16628576
OWN - NLM
STAT- MEDLINE
DCOM- 20060713
LR  - 20060818
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 78
IP  - 6
DP  - 2006 Jun
TI  - Time course characteristics of human herpesvirus 6 specific cellular immune 
      response and natural killer cell activity in patients with exanthema subitum.
PG  - 792-9
AB  - The time-course of cell-mediated immunity in exanthema subitum is not well 
      documented. The lymphoproliferative response to purified human herpesvirus 6 
      (HHV-6) antigen and to phytohemagglutinin was measured and natural killer (NK) 
      cell activities determined in three consecutive specimens obtained biweekly from 
      18 young children and infants with exanthema subitum. Virus isolation and PCR 
      detection of virus DNA and determination of neutralization antibody to HHV-6 and 
      -7 were also carried out. The magnitude of the HHV-6 specific lymphoproliferative 
      response varied; however, in most cases the time course kinetics revealed a low 
      response in the acute phase with a subsequent gradual increase. In contrast, NK 
      cell activities were high in the acute phase and declined gradually during 
      convalescence. The lymphoproliferative response to phytohemagglutinin did not 
      show a consistent trend in kinetics of time; however, dynamic changes in activity 
      were observed in patients during the acute and convalescent periods. The results 
      suggest that NK cells play a major role in resolving acute phase infection while 
      specific lymphocyte activity develops later. The cause of the delayed development 
      of HHV-6 specific lymphoproliferative response is unknown. The 
      lymphoproliferative response to phytohemagglutinin ratios implied that HHV-6 
      infection has some impact on host T-cell immunity during the course of exanthema 
      subitum.
FAU - Kumagai, Takuji
AU  - Kumagai T
AD  - Pediatric Allergy and Infectious Diseases Society of Sapporo, Kumagai Pediatric 
      Clinic, Sapporo, Hokkaido, Japan. tkuma@mb.infosnow.ne.jp
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
FAU - Yoshida, Mariko
AU  - Yoshida M
FAU - Okui, Toyo
AU  - Okui T
FAU - Ihira, Masaru
AU  - Ihira M
FAU - Nagata, Nobuo
AU  - Nagata N
FAU - Yano, Shoki
AU  - Yano S
FAU - Shiraki, Kimiyasu
AU  - Shiraki K
FAU - Yamada, Masao
AU  - Yamada M
FAU - Ichihara, Kiyoshi
AU  - Ichihara K
FAU - Asano, Yoshizo
AU  - Asano Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
SB  - IM
EIN - J Med Virol. 2006 Sep;78(9):1256
MH  - Cell Proliferation
MH  - Exanthema Subitum/*immunology/*virology
MH  - Female
MH  - Herpesvirus 6, Human/*immunology
MH  - Herpesvirus 7, Human/immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Infant
MH  - Killer Cells, Natural/*metabolism
MH  - Male
MH  - Roseolovirus Infections/immunology
MH  - Time Factors
EDAT- 2006/04/22 09:00
MHDA- 2006/07/14 09:00
CRDT- 2006/04/22 09:00
PHST- 2006/04/22 09:00 [pubmed]
PHST- 2006/07/14 09:00 [medline]
PHST- 2006/04/22 09:00 [entrez]
AID - 10.1002/jmv.20625 [doi]
PST - ppublish
SO  - J Med Virol. 2006 Jun;78(6):792-9. doi: 10.1002/jmv.20625.