PMID- 16629476
OWN - NLM
STAT- MEDLINE
DCOM- 20060721
LR  - 20191026
IS  - 0300-9149 (Print)
IS  - 0300-9149 (Linking)
VI  - 73
IP  - 1
DP  - 2006 Mar
TI  - [Prediction of occult cervical lymph node metastasis in patients with stage I -II 
      squamous cell carcinoma of the oral cavity].
PG  - 100-6
AB  - The presence of lymph node metastasis is the most important prognostic factor in 
      oral cancer. The purpose of this study was to find useful markers for predicting 
      occult cervical lymph node metastasis in patients with stage I or II squamous 
      cell carcinoma of the oral cavity. We investigated 6 clinicopathologic factors 
      and 2 genetic markers to predict late or occult cervical metastasis in 33 
      patients with stage I and II oral squamous cell carcinoma who underwent partial 
      glossectomy through the mouth without elective neck dissection. In this study, we 
      performed fluorescence in situ hybridization (FISH) with specimens obtained by 
      fine-needle aspiration biopsies (FNA biopsies) of primary oral cancer material, 
      to investigate numerical aberration of the gene. Late cervical lymph node 
      metastasis occurred in 16 of the 33 patients (48.5%) during follow-up after 
      treatment of the primary tumor. Factors significantly associated with the 
      development of cervical metastasis were the mode of invasion (p = 0.009), cyclin 
      D1 (p = 0.003) and EGFR numerical aberration (p = 0.024). The rate of 
      disease-free survival from metastatic disease was significantly lower in patients 
      with mode of invasion 4 C-4 D than in those with 1-3, and was significantly lower 
      in patients with cyclin D 1 or EGFR gene numerical aberrations than in those 
      without such aberrations (log rank test, p = 0.0064, p = 0.0016 or p = 0.0150). 
      Our results indicate that patients with stage I - II squamous cell carcinoma of 
      the oral cavity with the mode of invasion 4 C or 4 D, cyclin D 1 and EGFR gene 
      numerical aberration should be considered a high-risk group for late cervical 
      lymph node metastasis.
FAU - Myo, Kunihiro
AU  - Myo K
AD  - Maxillofacial Surgery, Department of Maxillofacial Reconstruction and Function, 
      Division of Maxillofacial/Neck Reconstruction, Graduate School, Tokyo Medical and 
      Dental University.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Kokubyo Gakkai Zasshi
JT  - Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan
JID - 0413677
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*pathology
MH  - Neck
MH  - Prognosis
EDAT- 2006/04/25 09:00
MHDA- 2006/07/22 09:00
CRDT- 2006/04/25 09:00
PHST- 2006/04/25 09:00 [pubmed]
PHST- 2006/07/22 09:00 [medline]
PHST- 2006/04/25 09:00 [entrez]
AID - 10.5357/koubyou.73.100 [doi]
PST - ppublish
SO  - Kokubyo Gakkai Zasshi. 2006 Mar;73(1):100-6. doi: 10.5357/koubyou.73.100.