PMID- 16630027
OWN - NLM
STAT- MEDLINE
DCOM- 20060628
LR  - 20211020
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 118
IP  - 1
DP  - 2006 May
TI  - NKT cells play critical roles in the induction of oral tolerance by inducing 
      regulatory T cells producing IL-10 and transforming growth factor beta, and by 
      clonally deleting antigen-specific T cells.
PG  - 101-11
AB  - Oral tolerance is the systemic unresponsiveness induced by orally administered 
      proteins. To explore the roles of natural killer T (NKT) cells in oral tolerance, 
      we induced oral tolerance to ovalbumin (OVA) in NKT cell-deficient mice. In 
      CD1d-/- mice, the induction of tolerance to orally administered high- or low-dose 
      OVA was impaired. Dendritic cells (DCs) in the Peyer's patches (PPs) of CD1d-/- 
      mice fed OVA showed high expression of major histocompatibility complex (MHC) 
      class II and B7 molecules, whereas DCs of control mice fed OVA expressed low 
      levels of these molecules. The adoptive transfer of NKT cells restored oral 
      tolerance and induction of tolerogenic DCs in the PPs and spleens of CD1d-/- 
      mice. Moreover, interleukin (IL)-10 and transforming growth factor (TGF)-beta1 
      production in vitro were reduced in cells from the spleen and PPs of CD1d-/- mice 
      compared with those of control mice fed OVA. The numbers of OVA-specific CD4+ 
      KJ1-26+ T cells were significantly reduced in the PPs and spleens of DO11.10 mice 
      fed OVA. In contrast, OVA-specific CD4+ KJ1-26+ T cells were not deleted in the 
      PPs or spleens of DO11.10 CD1d-/- mice. In conclusion, NKT cells were found to 
      play an indispensable role in oral tolerance by inducing regulatory T cells, and 
      clonally deleting antigen-specific CD4+ T cells.
FAU - Kim, Hyun Jung
AU  - Kim HJ
AD  - Department of Pathology, Seoul National University College of Medicine, 
      Chongno-gu, Seoul, Korea.
FAU - Hwang, Su Jin
AU  - Hwang SJ
FAU - Kim, Byoung Kwon
AU  - Kim BK
FAU - Jung, Kyeong Cheon
AU  - Jung KC
FAU - Chung, Doo Hyun
AU  - Chung DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Administration, Oral
MH  - Adoptive Transfer
MH  - Animals
MH  - Clonal Deletion/*immunology
MH  - Dendritic Cells/immunology
MH  - Dose-Response Relationship, Immunologic
MH  - Interleukin-10/*biosynthesis
MH  - Killer Cells, Natural/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Ovalbumin/immunology
MH  - Peyer's Patches/immunology
MH  - Spleen/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Transforming Growth Factor beta/*biosynthesis
PMC - PMC1782272
EDAT- 2006/04/25 09:00
MHDA- 2006/06/29 09:00
PMCR- 2007/05/01
CRDT- 2006/04/25 09:00
PHST- 2006/04/25 09:00 [pubmed]
PHST- 2006/06/29 09:00 [medline]
PHST- 2006/04/25 09:00 [entrez]
PHST- 2007/05/01 00:00 [pmc-release]
AID - IMM2346 [pii]
AID - 10.1111/j.1365-2567.2006.02346.x [doi]
PST - ppublish
SO  - Immunology. 2006 May;118(1):101-11. doi: 10.1111/j.1365-2567.2006.02346.x.