PMID- 16630178
OWN - NLM
STAT- MEDLINE
DCOM- 20060811
LR  - 20171116
IS  - 0303-6987 (Print)
IS  - 0303-6987 (Linking)
VI  - 33
IP  - 4
DP  - 2006 Apr
TI  - t(14;18)(q32;q21) involving IGH and MALT1 is uncommon in cutaneous MALT lymphomas 
      and primary cutaneous diffuse large B-cell lymphomas.
PG  - 286-92
AB  - BACKGROUND: t(14;18)(q32;q21) involving IGH and MALT1 has been demonstrated in 
      cutaneous MALT lymphomas and in one case of primary cutaneous diffuse large 
      B-cell lymphoma (DLBCL). However, the incidence of IGH/MALT1 translocations in 
      these forms of cutaneous lymphoma remains unclear. METHODS: We performed paraffin 
      section interphase fluorescence in situ hybridization (FISH) analysis using MALT1 
      and IGH break-apart probes on 16 cutaneous MALT lymphomas and 16 primary 
      cutaneous DLBCL in order to assess the frequency of IGH/MALT1 translocations and 
      to screen for other potential translocations involving the IGH or MALT1 loci. 
      RESULTS: Translocations involving MALT1 were not detected in any of 16 cutaneous 
      MALT lymphomas or 16 primary cutaneous DLBCL. Of the 12 MALT lymphomas that could 
      be analyzed for an IGH translocation, all were negative. In contrast, four of the 
      13 cases (31%) of primary cutaneous DLBCL that could be analyzed for 
      translocations involving IGH were positive. Subsequent FISH analysis demonstrated 
      one of these to be an IGH/BCL2 translocation and one to be a CMYC/IGH 
      translocation, while the translocation partners in the remaining two cases are 
      currently unidentified. CONCLUSIONS: This study demonstrates that translocations 
      involving MALT1, including IGH/MALT1, are uncommon in cutaneous MALT lymphomas 
      and primary cutaneous DLBCL. Other translocations involving IGH also are not 
      involved in the pathogenesis of at least most cutaneous MALT lymphomas. In 
      contrast, primary cutaneous DLBCL may contain one of several IGH translocations 
      in a minority of cases.
FAU - Wongchaowart, Nicholas T
AU  - Wongchaowart NT
AD  - Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH 
      44195, USA.
FAU - Kim, Bong
AU  - Kim B
FAU - Hsi, Eric D
AU  - Hsi ED
FAU - Swerdlow, Steven H
AU  - Swerdlow SH
FAU - Tubbs, Raymond R
AU  - Tubbs RR
FAU - Cook, James R
AU  - Cook JR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Neoplasm Proteins)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Caspases/*genetics
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 18
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics
MH  - Male
MH  - Middle Aged
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - Neoplasm Proteins/*genetics
MH  - Paraffin Embedding
MH  - Skin Neoplasms/*genetics
MH  - *Translocation, Genetic
EDAT- 2006/04/25 09:00
MHDA- 2006/08/12 09:00
CRDT- 2006/04/25 09:00
PHST- 2006/04/25 09:00 [pubmed]
PHST- 2006/08/12 09:00 [medline]
PHST- 2006/04/25 09:00 [entrez]
AID - CUP459 [pii]
AID - 10.1111/j.0303-6987.2006.00459.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 2006 Apr;33(4):286-92. doi: 10.1111/j.0303-6987.2006.00459.x.