PMID- 16631352
OWN - NLM
STAT- MEDLINE
DCOM- 20060908
LR  - 20221207
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 84
IP  - 1
DP  - 2006 May
TI  - No association between the brain-derived neurotrophic factor gene and 
      schizophrenia in a Japanese population.
PG  - 29-35
AB  - Brain-derived neurotrophic factor (BDNF) plays important roles in the survival, 
      maintenance and growth of neurons. Several studies have indicated that BDNF is 
      likely to be related to the pathogenesis of schizophrenia. Recent genetic 
      analyses have revealed that BDNF gene polymorphisms are associated with 
      schizophrenia, although contradictory negative findings have also been reported. 
      To assess whether three BDNF gene polymorphisms (rs988748, C132T and rs6265) 
      could be implicated in vulnerability to schizophrenia, we conducted a 
      case-control association analysis (349 patients and 423 controls) in Japanese 
      subjects. We found no association between these BDNF gene polymorphisms and 
      schizophrenia using both single-marker and haplotype analyses. The results of the 
      present study suggest that these three BDNF gene polymorphisms do not play major 
      roles in conferring susceptibility to schizophrenia in a Japanese population. 
      However, further studies assessing the associations between these BDNF gene 
      polymorphisms and schizophrenia should be performed in several other ethnic 
      populations.
FAU - Watanabe, Yuichiro
AU  - Watanabe Y
AD  - Department of Psychiatry, Niigata University Graduate School of Medical and 
      Dental Sciences, Asahimachi-dori 1-757, Niigata 951-8510, Japan.
FAU - Muratake, Tatsuyuki
AU  - Muratake T
FAU - Kaneko, Naoshi
AU  - Kaneko N
FAU - Nunokawa, Ayako
AU  - Nunokawa A
FAU - Someya, Toshiyuki
AU  - Someya T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060421
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Schizophrenia/*ethnology/*genetics
EDAT- 2006/04/25 09:00
MHDA- 2006/09/09 09:00
CRDT- 2006/04/25 09:00
PHST- 2005/12/29 00:00 [received]
PHST- 2006/02/27 00:00 [revised]
PHST- 2006/03/01 00:00 [accepted]
PHST- 2006/04/25 09:00 [pubmed]
PHST- 2006/09/09 09:00 [medline]
PHST- 2006/04/25 09:00 [entrez]
AID - S0920-9964(06)00113-7 [pii]
AID - 10.1016/j.schres.2006.03.011 [doi]
PST - ppublish
SO  - Schizophr Res. 2006 May;84(1):29-35. doi: 10.1016/j.schres.2006.03.011. Epub 2006 
      Apr 21.