PMID- 16631934
OWN - NLM
STAT- MEDLINE
DCOM- 20060726
LR  - 20061115
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 175
IP  - 1-2
DP  - 2006 Jun
TI  - BDNF: a missing link between sympathetic dysfunction and inflammatory disease?
PG  - 118-27
AB  - Nerve growth factor (NGF) plays a role in sympathetic neuron integrity and 
      survival. Brain-derived neurotrophic factor (BDNF) also has trophic effects on 
      sympathetic neurons. We report here the serendipitous finding that co-treatment 
      of hippocampus with BDNF and the NGF antagonist TrkA-Fc leads to perivascular 
      inflammation and marked vasoconstriction. This effect is not observed with either 
      reagent alone or in combination with other control proteins. Because NGF supports 
      sympathetic neuron health, we tested the hypothesis that BDNF combined with 
      sympathetic compromise caused this effect. Superior cervical ganglia were removed 
      bilaterally with concurrent BDNF infusion into hippocampus. Perivascular 
      inflammation was observed at 3 days, but not 12 days post treatment, when 
      sympathetic terminals had receded, suggesting that the presence of these 
      terminals was necessary for inflammation. Since sympathetic dysfunction may lead 
      to compensatory overactivity of norepinephrine (NE) signaling, we co-infused BDNF 
      with NE in the hippocampus and observed perivascular inflammation. In humans, 
      sympathetic overactivity has been reported in a variety of vascular diseases. 
      Some of these diseases, e.g. primary Raynaud's, are not accompanied by serious 
      inflammatory disease whereas others, such as scleroderma and systemic lupus, are. 
      We speculate that BDNF may contribute to the transformation of sympathetic 
      dysfunction to inflammatory disease.
FAU - Kasselman, Lora J
AU  - Kasselman LJ
AD  - Neuropsychology Doctoral Subprogram, Graduate Center of the City University of 
      New York, USA.
FAU - Sideris, Alexandra
AU  - Sideris A
FAU - Bruno, Chantal
AU  - Bruno C
FAU - Perez, William R
AU  - Perez WR
FAU - Cai, Ning
AU  - Cai N
FAU - Nicoletti, Jamee N
AU  - Nicoletti JN
FAU - Wiegand, Stanley J
AU  - Wiegand SJ
FAU - Croll, Susan D
AU  - Croll SD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060424
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Autonomic Nervous System 
      Diseases/*immunology/*metabolism/pathology/physiopathology
MH  - Brain Edema/*immunology/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*physiology
MH  - Hippocampus/metabolism
MH  - Inflammation/metabolism/physiopathology
MH  - Infusion Pumps
MH  - Neurons/immunology/metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2006/04/25 09:00
MHDA- 2006/07/27 09:00
CRDT- 2006/04/25 09:00
PHST- 2005/09/09 00:00 [received]
PHST- 2006/03/12 00:00 [revised]
PHST- 2006/03/15 00:00 [accepted]
PHST- 2006/04/25 09:00 [pubmed]
PHST- 2006/07/27 09:00 [medline]
PHST- 2006/04/25 09:00 [entrez]
AID - S0165-5728(06)00087-7 [pii]
AID - 10.1016/j.jneuroim.2006.03.008 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2006 Jun;175(1-2):118-27. doi: 10.1016/j.jneuroim.2006.03.008. 
      Epub 2006 Apr 24.