PMID- 16631971
OWN - NLM
STAT- MEDLINE
DCOM- 20060927
LR  - 20220408
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1763
IP  - 7
DP  - 2006 Jul
TI  - Copper trafficking to the mitochondrion and assembly of copper metalloenzymes.
PG  - 759-72
AB  - Copper is required within the mitochondrion for the function of two 
      metalloenzymes, cytochrome c oxidase (CcO) and superoxide dismutase (Sod1). 
      Copper metallation of these two enzymes occurs within the mitochondrial 
      intermembrane space and is mediated by metallochaperone proteins. Cox17 is a key 
      copper donor to two accessory proteins, Sco1 and Cox11, to form the two copper 
      centers in the mature CcO complex. Ccs1 is the necessary metallochaperone for the 
      copper metallation of Sod1 in the IMS as well as within the cytoplasm where the 
      bulk of Sod1 resides. Copper ions used in the metallation of CcO and Sod1 appear 
      to be provided by a novel copper pool within the mitochondrial matrix. This 
      review documents copper ion shuttling within the mitochondrion and the proteins 
      that mediate assembly of active CcO and Sod1.
FAU - Cobine, Paul A
AU  - Cobine PA
AD  - Departments of Medicine and Biochemistry, University of Utah Health Sciences 
      Center, Salt Lake City, UT 84132, USA.
FAU - Pierrel, Fabien
AU  - Pierrel F
FAU - Winge, Dennis R
AU  - Winge DR
LA  - eng
GR  - ES 03817/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20060331
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 789U1901C5 (Copper)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Biological Transport
MH  - Copper/*metabolism
MH  - Electron Transport Complex IV/chemistry/*metabolism
MH  - Mitochondria/*metabolism
MH  - Models, Molecular
MH  - Protein Conformation
RF  - 94
EDAT- 2006/04/25 09:00
MHDA- 2006/09/28 09:00
CRDT- 2006/04/25 09:00
PHST- 2005/12/21 00:00 [received]
PHST- 2006/03/03 00:00 [revised]
PHST- 2006/03/05 00:00 [accepted]
PHST- 2006/04/25 09:00 [pubmed]
PHST- 2006/09/28 09:00 [medline]
PHST- 2006/04/25 09:00 [entrez]
AID - S0167-4889(06)00053-X [pii]
AID - 10.1016/j.bbamcr.2006.03.002 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2006 Jul;1763(7):759-72. doi: 10.1016/j.bbamcr.2006.03.002. 
      Epub 2006 Mar 31.