PMID- 16632345
OWN - NLM
STAT- MEDLINE
DCOM- 20060824
LR  - 20060605
IS  - 0959-8049 (Print)
IS  - 0959-8049 (Linking)
VI  - 42
IP  - 9
DP  - 2006 Jun
TI  - Stem cell plasticity and tumour formation.
PG  - 1247-56
AB  - Stem cell plasticity refers to the ability of certain stem cells to switch 
      lineage determination and generate unexpected cell types. This review applies 
      largely to bone marrow cells (BMCs), which appear to contribute positively to the 
      regeneration of several damaged non-haematopoietic tissues. This beneficial 
      effect on regeneration may be a direct result of BMCs giving rise to organ 
      parenchymal cells. Alternatively, it could be due to BMCs fusing with existing 
      parenchymal cells, or providing paracrine growth factor support, or contributing 
      to neovascularisation. In the context of oncology, BMC derivation of the tumour 
      stroma and vasculature has profound biological and therapeutic implications, and 
      there are several examples of carcinomas seemingly being derived from BMCs.
FAU - Alison, Malcolm R
AU  - Alison MR
AD  - Centre for Diabetes and Metabolic Medicine, Queen Mary' School of Medicine and 
      Dentistry, Institute of Cell and Molecular Science, 4 Newark Street, Whitechapel, 
      London E1 2AT, UK. m.alison@qmul.ac.uk
FAU - Lovell, Matthew J
AU  - Lovell MJ
FAU - Direkze, Natalie C
AU  - Direkze NC
FAU - Wright, Nicholas A
AU  - Wright NA
FAU - Poulsom, Richard
AU  - Poulsom R
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060502
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*pathology
MH  - Cell Fusion
MH  - Cell Transformation, Neoplastic/pathology
MH  - Humans
MH  - Mice
MH  - Neoplasms/blood supply/*pathology
MH  - Stem Cells/*pathology
RF  - 95
EDAT- 2006/04/25 09:00
MHDA- 2006/08/25 09:00
CRDT- 2006/04/25 09:00
PHST- 2006/01/23 00:00 [received]
PHST- 2006/01/23 00:00 [accepted]
PHST- 2006/04/25 09:00 [pubmed]
PHST- 2006/08/25 09:00 [medline]
PHST- 2006/04/25 09:00 [entrez]
AID - S0959-8049(06)00189-4 [pii]
AID - 10.1016/j.ejca.2006.01.034 [doi]
PST - ppublish
SO  - Eur J Cancer. 2006 Jun;42(9):1247-56. doi: 10.1016/j.ejca.2006.01.034. Epub 2006 
      May 2.