PMID- 16632412 OWN - NLM STAT- MEDLINE DCOM- 20060925 LR - 20131121 IS - 1566-0702 (Print) IS - 1566-0702 (Linking) VI - 126-127 DP - 2006 Jun 30 TI - Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview. PG - 30-8 AB - Neurotrophins, and in particular BDNF, play important roles in proliferation, differentiation and survival of neurons during development, as well as in the synaptic activity and plasticity in many groups of mature neurons. Several lines of evidence suggest that BDNF and its high affinity receptor TrkB contribute to food intake and body weight control. In rodents, pharmacological treatments with BDNF induce reduction in food intake, whereas genetic models with an altered BDNF/TrkB signalling display hyperphagia and obesity. Genetic studies in humans have shown that mutations in the BDNF or TrkB genes may account for certain types of obesity or other forms of eating disorders. Since circulating levels of BDNF correlate with eating disorders in humans and peripheral BDNF treatments reduce hyperphagia and hyperglycaemia in obese diabetic rodents, an endocrine role of BDNF appears plausible and requires further investigation. A central anorectic action of BDNF has also been documented, with a primary focus on the hypothalamus and a more recent highlight on the brainstem integrator of energy homeostasis, the dorsal vagal complex. In this review, we will briefly present neurotrophins and their receptors and focus on experimental evidence which point out BDNF as a signalling component of food intake regulation, with a particular emphasis on the localization of the central anorectic action of BDNF. FAU - Lebrun, Bruno AU - Lebrun B AD - Laboratoire de Physiologie Neurovegetative (PNV), UMR Universite Paul Cezanne Aix, Marseille III, CNRS (UMR 6153), INRA (UMR 1147), Faculte des sciences et techniques, BP 351, 13397 Marseille cedex 20, France. bruno.lebrun@univ.u-3mrs.fr FAU - Bariohay, Bruno AU - Bariohay B FAU - Moyse, Emmanuel AU - Moyse E FAU - Jean, Andre AU - Jean A LA - eng PT - Journal Article PT - Review DEP - 20060424 PL - Netherlands TA - Auton Neurosci JT - Autonomic neuroscience : basic & clinical JID - 100909359 RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.7.10.1 (Receptor, trkB) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Animals MH - Appetite Regulation/*physiology MH - Brain-Derived Neurotrophic Factor/*physiology MH - Glucose/metabolism MH - Humans MH - Receptor, trkB/physiology RF - 95 EDAT- 2006/04/25 09:00 MHDA- 2006/09/26 09:00 CRDT- 2006/04/25 09:00 PHST- 2006/01/16 00:00 [received] PHST- 2006/02/27 00:00 [accepted] PHST- 2006/04/25 09:00 [pubmed] PHST- 2006/09/26 09:00 [medline] PHST- 2006/04/25 09:00 [entrez] AID - S1566-0702(06)00078-6 [pii] AID - 10.1016/j.autneu.2006.02.027 [doi] PST - ppublish SO - Auton Neurosci. 2006 Jun 30;126-127:30-8. doi: 10.1016/j.autneu.2006.02.027. Epub 2006 Apr 24.