PMID- 16632819
OWN - NLM
STAT- MEDLINE
DCOM- 20060517
LR  - 20071114
IS  - 1526-7598 (Electronic)
IS  - 0003-2999 (Linking)
VI  - 102
IP  - 5
DP  - 2006 May
TI  - Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to 
      suppress the temporal summation that contributes to minimum alveolar 
      concentration?
PG  - 1412-8
AB  - Antagonism of N-methyl-d-aspartate (NMDA) receptors markedly decreases the 
      minimum alveolar concentration (MAC) of inhaled anesthetics. To assess the 
      importance of suppression of the temporal summation NMDA receptor component of 
      MAC, we stimulated the tail of rats with trains of electrical pulses of varying 
      interstimulus intervals (ISIs) and determined the inhaled anesthetic 
      concentrations (crossover concentrations) that suppressed movement at different 
      ISIs. The slopes of crossover concentrations versus ISIs provided a measure of 
      temporal summation for each anesthetic. We studied five anesthetics that differ 
      widely in their in vitro capacity to block NMDA receptors. To block NMDA receptor 
      transmission and reveal the NMDA receptor component, the NMDA receptor 
      antagonist, MK801, was separately added during each anesthetic. Halothane, 
      isoflurane, and hexafluorobenzene did not appreciably suppress the NMDA receptor 
      components of temporal summation, which contributed to 21% to 29% of MAC (P < 
      0.05 for each). Xenon and o-difluorobenzene suppressed these components to 8% to 
      0%, respectively, of MAC (neither significant), consistent with their greater 
      NMDA receptor blocking action in vitro. NMDA receptor blockade may contribute to 
      the MAC produced by inhaled anesthetics that potently inhibit NMDA receptors in 
      vitro but not those that have a limited in vitro effect.
FAU - Dutton, Robert C
AU  - Dutton RC
AD  - Department of Anesthesia and Perioperative Care, University of California, San 
      Francisco, San Francisco, California 94143-0464, USA. dutton20@comcast.net
FAU - Laster, Michael J
AU  - Laster MJ
FAU - Xing, Yilei
AU  - Xing Y
FAU - Sonner, James M
AU  - Sonner JM
FAU - Raines, Douglas E
AU  - Raines DE
FAU - Solt, Ken
AU  - Solt K
FAU - Eger, Edmond I 2nd
AU  - Eger EI 2nd
LA  - eng
GR  - 1POIGM47818/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Anesth Analg
JT  - Anesthesia and analgesia
JID - 1310650
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Anesthetics, Inhalation/*administration & dosage/pharmacokinetics
MH  - Animals
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Male
MH  - Pulmonary Alveoli/drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism
MH  - Time Factors
EDAT- 2006/04/25 09:00
MHDA- 2006/05/18 09:00
CRDT- 2006/04/25 09:00
PHST- 2006/04/25 09:00 [pubmed]
PHST- 2006/05/18 09:00 [medline]
PHST- 2006/04/25 09:00 [entrez]
AID - 102/5/1412 [pii]
AID - 10.1213/01.ane.0000205759.67123.76 [doi]
PST - ppublish
SO  - Anesth Analg. 2006 May;102(5):1412-8. doi: 10.1213/01.ane.0000205759.67123.76.