PMID- 16634991
OWN - NLM
STAT- MEDLINE
DCOM- 20061109
LR  - 20221207
IS  - 1462-8902 (Print)
IS  - 1462-8902 (Linking)
VI  - 8
IP  - 3
DP  - 2006 May
TI  - Effects of running exercise on fibre-type distribution of soleus and plantaris 
      muscles in diabetic Otsuka Long-Evans Tokushima fatty rats.
PG  - 311-21
AB  - AIM: Effect of running exercise on fibre-type distributions of the slow soleus 
      and fast plantaris muscles was investigated in male Otsuka Long-Evans Tokushima 
      fatty rats (OLETF) as an animal model of spontaneous type 2 diabetes mellitus. 
      METHODS: Five-week-old OLETF rats were allowed to exercise voluntarily in running 
      wheels for 32 days and the data were compared with those of age-matched 
      non-exercised OLETF and non-diabetic Long-Evans Tokushima Otsuka rats (LETO). 
      RESULTS: In the soleus muscle, a higher percentage of type I fibres was observed 
      in non-exercised OLETF rats compared with LETO rats, and there were no type IIA 
      fibres in non-exercised OLETF rats. In the plantaris muscle, a higher percentage 
      of type IIB fibres and a lower percentage of type I and type IIA fibres were 
      observed in non-exercised OLETF rats compared with LETO rats. In contrast, there 
      were no differences in the fibre-type distribution of soleus and plantaris 
      muscles between exercised OLETF and LETO rats. The body weight and type I fibre 
      percentage of the soleus muscle were related to the running distance in exercised 
      OLETF rats. White adipose tissue weight, HbA(1c) and blood insulin and glucose 
      concentrations were lower in exercised OLETF rats than in non-exercised OLETF 
      rats, irrespective of the running distance. There was a difference in the 
      gene-expression pattern of the soleus muscle among LETO rats, non-exercised OLETF 
      and exercised OLETF rats. CONCLUSION: Running exercise can inhibit 
      diabetes-associated type shifting of fibres, which is more apparent with 
      postnatal growth, in skeletal muscles of diabetic OLETF rats, as a result of mRNA 
      expression change in muscle.
FAU - Yasuda, K
AU  - Yasuda K
AD  - Department of Endocrinology, Metabolism and Diabetes Mellitus, Kinki University 
      School of Medicine, Osaka-Sayama, Japan. yasuda2@tom.life.h.kyoto-u.ac.jp
FAU - Adachi, T
AU  - Adachi T
FAU - Kikuchi, N
AU  - Kikuchi N
FAU - Tsujimoto, G
AU  - Tsujimoto G
FAU - Aoki, N
AU  - Aoki N
FAU - Tsuda, K
AU  - Tsuda K
FAU - Ishihara, A
AU  - Ishihara A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
SB  - IM
MH  - Adipose Tissue/pathology
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight
MH  - Diabetes Mellitus, Experimental/metabolism/*pathology/physiopathology
MH  - Diabetes Mellitus, Type 2/metabolism/*pathology/physiopathology
MH  - Eating
MH  - Glycated Hemoglobin/metabolism
MH  - Insulin/blood
MH  - Male
MH  - *Motor Activity
MH  - Muscle Fibers, Skeletal/enzymology/pathology
MH  - Muscle, Skeletal/enzymology/*pathology
MH  - Organ Size
MH  - Rats
MH  - Rats, Inbred OLETF
MH  - Succinate Dehydrogenase/metabolism
EDAT- 2006/04/26 09:00
MHDA- 2006/11/11 09:00
CRDT- 2006/04/26 09:00
PHST- 2006/04/26 09:00 [pubmed]
PHST- 2006/11/11 09:00 [medline]
PHST- 2006/04/26 09:00 [entrez]
AID - DOM507 [pii]
AID - 10.1111/j.1463-1326.2005.00507.x [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2006 May;8(3):311-21. doi: 10.1111/j.1463-1326.2005.00507.x.