PMID- 16639473
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20211020
IS  - 0828-282X (Print)
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 22
IP  - 5
DP  - 2006 Apr
TI  - Skeletal muscle endurance and muscle metabolism in patients with chronic heart 
      failure.
PG  - 387-92
AB  - BACKGROUND: Alterations in skeletal muscle function are known to contribute to 
      exercise intolerance in patients with chronic heart failure (CHF). OBJECTIVES: To 
      evaluate whether muscle isometric endurance can be objectively measured and 
      whether it is related to skeletal muscle metabolism in CHF. METHODS: Isometric 
      endurance of the vastus lateralis, measured as time to fatigue (T(F)), was 
      evaluated in 25 patients with CHF (55+/-8 years of age [mean +/- SD]) and 18 
      healthy subjects (HS) (62+/-6 years of age [mean +/- SD]). Median frequency of 
      surface electromyography was obtained from spectral analysis using a fast Fourier 
      transformation. Citrate synthase (CS), 3-hydroxyacyl-CoA dehydrogenase (HADH), 
      hexokinase (HK) and phosphofructokinase (PFK) activities were determined from the 
      right vastus lateralis muscle. RESULTS: T(F) was lower in CHF patients than in HS 
      (49+/-4 s and 80+/-7 s, respectively; P<0.01). Muscle fatigue was present at the 
      end of the endurance test in both groups (median frequency breakpoint at 
      mid-exercise for both groups [P<0.05]). CS (P<0.01) and HK (P<0.01) activities 
      were lower in CHF patients than in HS, but PFK activity was higher (P<0.05). T(F) 
      correlated significantly with CS (r=0.50), HADH (r=0.42), PFK (r=-0.47) and HK 
      (r=0.41) activities and the PFK/CS ratio (r=-0.39) when both groups were 
      considered, and with HADH (r=0.47) and PFK (r=-0.57) activities for the CHF group 
      alone (all P<0.05). CONCLUSIONS: These results suggest that isometric endurance 
      of the vastus lateralis muscle is reduced in patients with CHF and that it is 
      related to a reduced muscle oxidative capacity.
FAU - Brassard, Patrice
AU  - Brassard P
AD  - Centre de recherche, Hopital Laval, Institut universitaire de cardiologie et de 
      pneumologie, Universite Laval, Ste-Foy, Quebec, Canada.
FAU - Maltais, Francois
AU  - Maltais F
FAU - Noel, Martin
AU  - Noel M
FAU - Doyon, Jean-Francois
AU  - Doyon JF
FAU - LeBlanc, Pierre
AU  - LeBlanc P
FAU - Allaire, Joakim
AU  - Allaire J
FAU - Simard, Clermont
AU  - Simard C
FAU - Leblanc, Marie-Helene
AU  - Leblanc MH
FAU - Poirier, Paul
AU  - Poirier P
FAU - Jobin, Jean
AU  - Jobin J
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
SB  - IM
MH  - Body Size/physiology
MH  - Exercise/physiology
MH  - Female
MH  - Heart Failure/*metabolism/*physiopathology
MH  - Humans
MH  - Isometric Contraction/physiology
MH  - Male
MH  - Middle Aged
MH  - Muscle Fatigue/physiology
MH  - Muscle, Skeletal/*metabolism/*physiopathology
MH  - Oxidative Phosphorylation
MH  - Oxygen Consumption/physiology
MH  - *Physical Endurance/physiology
PMC - PMC2560533
EDAT- 2006/04/28 09:00
MHDA- 2006/06/14 09:00
PMCR- 2007/04/01
CRDT- 2006/04/28 09:00
PHST- 2006/04/28 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/04/28 09:00 [entrez]
PHST- 2007/04/01 00:00 [pmc-release]
AID - S0828-282X(06)70923-0 [pii]
AID - cjc220387 [pii]
AID - 10.1016/s0828-282x(06)70923-0 [doi]
PST - ppublish
SO  - Can J Cardiol. 2006 Apr;22(5):387-92. doi: 10.1016/s0828-282x(06)70923-0.