PMID- 16640037
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20060427
IS  - 1608-8115 (Print)
IS  - 1608-8115 (Linking)
VI  - 46
IP  - 6
DP  - 2005 Nov-Dec
TI  - Allogeneic related bone marrow transplantation in children--a single center 
      experience.
PG  - 352-5
AB  - We report our single-center experience with related allogeneic bone marrow 
      transplantation (BMT) in pediatric recipients between April 1998 and December 
      2004. Allogeneic bone marrow grafts from 19 donors (18 human leukocyte antigen 
      (HLA)-matched sibling donors and 1 one antigen-mismatched related donor) were 
      transplanted into patients aged 3-17 years (16 with leukemia and 3 with 
      non-malignant disease). The patients received a cell dose, with median total 
      nucleated cell dose of 3.9 x 10(8)/kg (range, 0.7 - 8.7 x 10(8)) and median CD 
      34+ cell dose of 3.0 x 10(6)/g (range, 0.3 - 9.8 x 10(6)). Seventeen patients 
      (89.4%) engrafted after a median of 19 days (range 14-20 days). Acute graft 
      versus host disease (GVHD) grade II to IV developed in 8 patients (42. 1%), and 
      limited chronic GVHD developed in 2 evaluable patients (10.5%). Twelve of the 19 
      patients were alive at a median follow-up of 1460 days (range, 270-2260 days). 
      Full chimeric hematopoiesis was maintained in 11 of these 12 patients. Six 
      patients (31.6%) had relapse of their underlying malignant disease, and one of 
      them is still alive. Seven patients died (5 because of relapse and/or disease 
      progression and 2 because of infectious complication). The underlying diseases 
      were acute lymphoblastic leukemia (ALL; 4 cases: 3 CR2, 1 Ph+), acute myeloid 
      leukemia (AML; 2 cases: 1 CR2, 1 refractory), and juvenile chronic myelogenous 
      leukemia (JCML; 1 case). Relapsed leukemia at an extramedullary site occurred in 
      2 patients with ALL after BMT. Although our data should be interpreted cautiously 
      considering the limited number of patients, isolated extramedullary relapse seems 
      to be common after allogeneic BMT.
FAU - Chen, Shih-Hsiang
AU  - Chen SH
AD  - Divisions of Hematology and Oncology, Department of Medicine, Chang Gung 
      Children's Hospital, Taoyuan, Taiwan.
FAU - Hung, Iou-Jih
AU  - Hung IJ
FAU - Yang, Chao-Ping
AU  - Yang CP
FAU - Jaing, Tang-Her
AU  - Jaing TH
FAU - Fang, En-Chen
AU  - Fang EC
FAU - Yang, Shu-Ho
AU  - Yang SH
FAU - Tseng, Chen-Kan
AU  - Tseng CK
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Acta Paediatr Taiwan
JT  - Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi
JID - 100958202
SB  - IM
MH  - Adolescent
MH  - *Bone Marrow Transplantation/mortality
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Leukemia/therapy
MH  - Male
MH  - Recurrence
MH  - Retrospective Studies
MH  - Transplantation, Homologous
EDAT- 2006/04/28 09:00
MHDA- 2006/05/23 09:00
CRDT- 2006/04/28 09:00
PHST- 2006/04/28 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2006/04/28 09:00 [entrez]
PST - ppublish
SO  - Acta Paediatr Taiwan. 2005 Nov-Dec;46(6):352-5.