PMID- 16640876
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20111117
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 41
IP  - 3
DP  - 2006 Mar
TI  - [Association of soluble human leukocyte antigen DQB1 with recurrent spontaneous 
      abortion].
PG  - 152-4
AB  - OBJECTIVE: To investigate the relationship between the recurrent spontaneous 
      abortion and soluble human leukocyte antigen (HLA) DQB1 gene polymorphism. 
      METHODS: Sixty one cases with recurrent spontaneous abortion were included in 
      study group. Of them, 31 were anticardiolipin antibody (ACA) positive, while 30 
      were negative. Twenty eight cases were with early abortion, 22 were with late 
      abortion, and 11 were with both early and late abortions. Thirty six women 
      without abnormal pregnancy history were recruited as control group. HLA-DQB1 
      genotyping was carried out by polymerase chain reaction-restrictive fragment 
      length polymorphism (PCR-RFLP). RESULTS: The frequency of DQB1*0201allele in the 
      study group (16.4%, 20/122) was higher than that in the control group (8.3%, 
      6/72), but the difference was not statistically significant (P > 0.05). The 
      frequency of 57 site with non Asp in the study group was significantly higher 
      than that in the control group (P < 0.05). The frequencies of both DQB1*0201 and 
      *0303 were significantly different among early abortion, late abortion and both 
      early and late abortion groups (P < 0.05 and P < 0.05). The frequency of 
      DQB1*0201 was significantly higher in the early abortion group than that in the 
      late abortion group (P < 0.01). The frequency of DQB1*0303 was significantly 
      increased in the late abortion group when compared to that in the early group (P 
      < 0.01). The frequency of DQB1*0303 was found to be significantly higher in 
      patients with ACA positive than that in ACA negative group (P < 0.05). 
      CONCLUSION: The 57 site with non Asp may be a gene related to recurrent 
      spontaneous abortions. DQB1*0201 may be correlated to the early abortion, while 
      DQB1*0303 correlated to the late abortion and abortion with ACA positive.
FAU - Zheng, Mei-ling
AU  - Zheng ML
AD  - Department of Obstetrics and Gynecology, First Clinical College, Shanxi Medical 
      University, Taiyuan 030001, China.
FAU - Niu, Li-yun
AU  - Niu LY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Abortion, Habitual/*genetics/immunology
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Leukocytes/*immunology
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Pregnancy
EDAT- 2006/04/28 09:00
MHDA- 2008/02/15 09:00
CRDT- 2006/04/28 09:00
PHST- 2006/04/28 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2006/04/28 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2006 Mar;41(3):152-4.