PMID- 16641544
OWN - NLM
STAT- MEDLINE
DCOM- 20060512
LR  - 20190911
IS  - 0388-1350 (Print)
IS  - 0388-1350 (Linking)
VI  - 30 Spec No.
DP  - 2005 Dec
TI  - A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats.
PG  - 59-78
AB  - A two-generation reproductive toxicity study was conducted with 
      2,4-dichlorophenol (2,4-DCP), an agent suspected of exerting endocrine disrupting 
      effects. Wistar-Hannover rats, 24/sex/group, were given diet containing 2,4-DCP 
      at dose levels of 0, 500, 2000 or 8000 ppm to examine the potential effects of 
      the test substance on parental animals and their offspring over 2 successive 
      generations. Neither clear systemic nor reproductive toxicity of 2,4-DCP was 
      apparent in the 500 ppm group. In the 2000 ppm group, mean body weight gain and 
      food consumption of females were lowered significantly during the treatment 
      period. Effects on body weights and food consumption were more serious in the 
      8000 ppm group, both males and females being significantly affected. Reproductive 
      effects of the test substance were also observed in the 2000 and 8000 ppm groups 
      dose-dependently. Observations included significantly increased uterine weights 
      of F1 and/or F2 female weanlings and reduced numbers of implantation sites and 
      live births of F1 parental females. These results suggest that 2,4-DCP has weak 
      reproductive toxicity, possibly based on endocrine activity. However, the basic 
      mechanisms for apparent estrogenic effects of 2,4-DCP remain to be elucidated.
FAU - Aoyama, Hiroaki
AU  - Aoyama H
AD  - Laboratory of Reproductive Toxicology, Chemistry Division , Institute of 
      Environmental Toxicology, 4321 Uchimoriya-machi, Mitsukaido-shi, Ibaraki 
      303-0043, Japan. aoyama@iet.or.jp
FAU - Hojo, Hitoshi
AU  - Hojo H
FAU - Takahashi, Ken L
AU  - Takahashi KL
FAU - Shimizu, Naoko
AU  - Shimizu N
FAU - Araki, Masayuki
AU  - Araki M
FAU - Harigae, Michiko
AU  - Harigae M
FAU - Tanaka, Naoki
AU  - Tanaka N
FAU - Shirasaka, Noriko
AU  - Shirasaka N
FAU - Kuwahara, Maki
AU  - Kuwahara M
FAU - Nakashima, Nobuaki
AU  - Nakashima N
FAU - Yamamoto, Eri
AU  - Yamamoto E
FAU - Saka, Machiko
AU  - Saka M
FAU - Teramoto, Shoji
AU  - Teramoto S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Chlorophenols)
RN  - 0 (Endocrine Disruptors)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Chlorophenols/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Endocrine Disruptors/*toxicity
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reproduction/*drug effects
MH  - Toxicity Tests, Chronic/*methods
EDAT- 2006/04/28 09:00
MHDA- 2006/05/13 09:00
CRDT- 2006/04/28 09:00
PHST- 2006/04/28 09:00 [pubmed]
PHST- 2006/05/13 09:00 [medline]
PHST- 2006/04/28 09:00 [entrez]
AID - JST.JSTAGE/jts/30.S59 [pii]
AID - 10.2131/jts.30.s59 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2005 Dec;30 Spec No.:59-78. doi: 10.2131/jts.30.s59.