PMID- 16644198
OWN - NLM
STAT- MEDLINE
DCOM- 20060720
LR  - 20211203
IS  - 0955-2863 (Print)
IS  - 0955-2863 (Linking)
VI  - 17
IP  - 6
DP  - 2006 Jun
TI  - Role of amino acids in insulin signaling in adipocytes and their potential to 
      decrease insulin resistance of adipose tissue.
PG  - 374-8
AB  - Recently, our knowledge concerning the role of amino acids in signal transduction 
      in mammals has greatly improved. This significant advance is mainly due to the 
      remarkable discovery that the mammalian target of rapamycin (mTOR) protein 
      kinase, known to be activated in response to a large number of hormones, growth 
      factors and cytokines, is also under the tight control of branched-chain amino 
      acids. Actually, both inputs are necessary to fully activate the mTOR pathway, 
      the main function of which is to increase cell size, via the regulation of 
      translational processes. However, amino acids are able to modulate other 
      biological effects and appear to have unexpected actions, as evidenced by our 
      recent work in rat adipocytes. The aim of this review is to summarize novel 
      findings on the role of mTOR and amino acids in insulin signaling in adipocytes. 
      A possible beneficial impact of the use of amino acids in the treatment of 
      insulin resistance is discussed, and hypotheses about the molecular mechanisms 
      underlying their effect are proposed.
FAU - Hinault, Charlotte
AU  - Hinault C
AD  - INSERM, Unite 145, Institut Federatif de Recherche (IFR 50), 06107 Nice Cedex 02, 
      France.
FAU - Van Obberghen, Emmanuel
AU  - Van Obberghen E
FAU - Mothe-Satney, Isabelle
AU  - Mothe-Satney I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060427
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Amino Acids)
RN  - 0 (Insulin)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipocytes/*physiology
MH  - Amino Acids/*physiology
MH  - Animals
MH  - Biological Transport
MH  - Enzyme Activation/drug effects
MH  - Glucose/metabolism
MH  - Humans
MH  - Insulin/*physiology
MH  - Insulin Resistance/*physiology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Protein Kinases/physiology
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases
RF  - 34
EDAT- 2006/04/29 09:00
MHDA- 2006/07/21 09:00
CRDT- 2006/04/29 09:00
PHST- 2005/11/15 00:00 [received]
PHST- 2006/01/30 00:00 [revised]
PHST- 2006/02/22 00:00 [accepted]
PHST- 2006/04/29 09:00 [pubmed]
PHST- 2006/07/21 09:00 [medline]
PHST- 2006/04/29 09:00 [entrez]
AID - S0955-2863(06)00052-0 [pii]
AID - 10.1016/j.jnutbio.2006.02.008 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2006 Jun;17(6):374-8. doi: 10.1016/j.jnutbio.2006.02.008. Epub 
      2006 Apr 27.