PMID- 16644484
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20211203
IS  - 1567-5769 (Print)
IS  - 1567-5769 (Linking)
VI  - 6
IP  - 6
DP  - 2006 Jun
TI  - Suppressive effect of verproside isolated from Pseudolysimachion longifolium on 
      airway inflammation in a mouse model of allergic asthma.
PG  - 978-86
AB  - Allergic inflammation of the airways has a critical role in asthma development. 
      We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) 
      isolated from the extract of Pseudolysimachion longifolium on asthmatic 
      parameters--such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, 
      airway hyperresponsiveness and mucus hypersecretion--in an 
      OVA-sensitized/challenged mouse model. Verproside significantly inhibited the 
      increase of total IgE and the cytokines IL-4 and IL-13 in plasma and 
      bronchoalveolar lavage fluid, and also effectively suppressed airway 
      hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced 
      asthmatic mice. The efficacy of verproside was comparable to montelukast, an 
      anti-asthmatic drug that is currently available. These results suggest that 
      verproside could be a major marker in herbal medicines that are used for asthma 
      treatment, and could also act as a lead for anti-asthmatic drugs.
FAU - Oh, Sei-Ryang
AU  - Oh SR
AD  - Innunomodulator Research Laboratory, Korea Research Institute of Bioscience and 
      Biotechnology, Daejeon, 305-333, South Korea.
FAU - Lee, Mee Young
AU  - Lee MY
FAU - Ahn, Kyungseop
AU  - Ahn K
FAU - Park, Bo-Young
AU  - Park BY
FAU - Kwon, Ok-Kyuoung
AU  - Kwon OK
FAU - Joung, Hyouk
AU  - Joung H
FAU - Lee, Joongku
AU  - Lee J
FAU - Kim, Doo-Young
AU  - Kim DY
FAU - Lee, Sangku
AU  - Lee S
FAU - Kim, Joo Heon
AU  - Kim JH
FAU - Lee, Hyeong-Kyu
AU  - Lee HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060210
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Acetates)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Cyclopropanes)
RN  - 0 (Glucosides)
RN  - 0 (Interleukin-13)
RN  - 0 (Iridoid Glucosides)
RN  - 0 (Iridoids)
RN  - 0 (Plant Extracts)
RN  - 0 (Quinolines)
RN  - 0 (Sulfides)
RN  - 0 (verproside)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - MHM278SD3E (montelukast)
SB  - IM
MH  - Acetates/pharmacology
MH  - Animals
MH  - Anti-Asthmatic Agents/isolation & purification/pharmacology/therapeutic use
MH  - Asthma/chemically induced/*drug therapy
MH  - Bronchoalveolar Lavage Fluid/chemistry/cytology/immunology
MH  - Cyclopropanes
MH  - Disease Models, Animal
MH  - Female
MH  - Glucosides/isolation & purification/pharmacology/*therapeutic use
MH  - Immunoglobulin E/analysis/blood
MH  - Interleukin-13/analysis
MH  - Interleukin-4/analysis
MH  - Iridoid Glucosides
MH  - Iridoids/isolation & purification/pharmacology/*therapeutic use
MH  - Lung/drug effects/metabolism/pathology
MH  - Methacholine Chloride/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Structure
MH  - Mucus/metabolism
MH  - Ovalbumin/immunology
MH  - Plant Extracts/isolation & purification/pharmacology/therapeutic use
MH  - Pneumonia/chemically induced/*drug therapy
MH  - Pulmonary Eosinophilia/pathology
MH  - Quinolines/pharmacology
MH  - Sulfides
MH  - Veronica/*chemistry
EDAT- 2006/04/29 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/04/29 09:00
PHST- 2005/10/10 00:00 [received]
PHST- 2005/12/05 00:00 [revised]
PHST- 2006/01/11 00:00 [accepted]
PHST- 2006/04/29 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/04/29 09:00 [entrez]
AID - S1567-5769(06)00030-0 [pii]
AID - 10.1016/j.intimp.2006.01.010 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2006 Jun;6(6):978-86. doi: 10.1016/j.intimp.2006.01.010. 
      Epub 2006 Feb 10.