PMID- 16644899
OWN - NLM
STAT- MEDLINE
DCOM- 20061010
LR  - 20220408
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 318
IP  - 3
DP  - 2006 Sep
TI  - Role of matrix metalloproteinases in intestinal inflammation.
PG  - 933-8
AB  - Matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue 
      inhibitors of MMPs (TIMPs), are produced in the gastrointestinal tract by several 
      structural cells. The balance between MMPs and TIMPs is essential for many 
      physiological processes in the gut. However, imbalance between MMPs and TIMPs 
      plays an important role in the pathophysiology of diverse intestinal inflammatory 
      conditions. We reviewed the role of the MMP/TIMP system in the pathogenesis of 
      intestinal inflammatory diseases and pharmacologic perspectives for the use of 
      compounds that restore the MMP/TIMP balance.
FAU - Medina, Carlos
AU  - Medina C
AD  - School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, 
      Ireland.
FAU - Radomski, Marek W
AU  - Radomski MW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060427
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Colitis, Collagenous/*etiology
MH  - Disease Models, Animal
MH  - Diverticulitis/*etiology
MH  - Enterocolitis, Necrotizing/*etiology
MH  - Humans
MH  - Inflammatory Bowel Diseases/*etiology
MH  - Intestinal Mucosa/physiology
MH  - Intestines/immunology
MH  - Matrix Metalloproteinases/*physiology
MH  - Tissue Inhibitor of Metalloproteinases/physiology
RF  - 49
EDAT- 2006/04/29 09:00
MHDA- 2006/10/13 09:00
CRDT- 2006/04/29 09:00
PHST- 2006/04/29 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/04/29 09:00 [entrez]
AID - jpet.106.103465 [pii]
AID - 10.1124/jpet.106.103465 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2006 Sep;318(3):933-8. doi: 10.1124/jpet.106.103465. Epub 
      2006 Apr 27.