PMID- 16646404
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20140625
VI  - 20
IP  - 3
DP  - 2006 Feb
TI  - [The clinical significance of the expression of p63 gene in laryngeal squamous 
      cell carcinoma].
PG  - 119-21
AB  - OBJECTIVE: To study the expression and clinical significance of p63 gene in 
      laryngeal squamous cell carcinoma(LSCC). METHOD: The immunohistochemical 
      technique was used to detected the expression of p63 in 63 cases of LSCC, 45 
      cases of para-cancer tissues, 24 cases of lymph node metastasis, 40 cases of non 
      lymph node metastasis and 25 normal tissues. RESULT: The positive overexpression 
      rate of the p63 gene in LSCC (95.24%) and in matched metastatic lymph node 
      (83.3%) was significantly higher than para cancer tissues, non metastasis lymph 
      node and normal tissues (P<0.01). p63 gene expression was not correlation with 
      the clinical stages,clinical typing and pathological classification of the LSCC(P 
      >0.05). CONCLUSION: p63 gene had important clinic significance to the diagnosis 
      and differential diagnosis of the LSCC. It perhaps participate in regulation of 
      tumorigenesis in LSCC, and it may play negative feedback action in the 
      development of LSCC.
FAU - Jia, Haiying
AU  - Jia H
AD  - Departament of Otorhinolaryngology, the First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
FAU - Wang, Jiqun
AU  - Wang J
FAU - Shan, Yanchun
AU  - Shan Y
FAU - Hou, Jinghui
AU  - Hou J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (CKAP4 protein, human)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Membrane Proteins/*metabolism
MH  - Middle Aged
MH  - Neoplasm Staging
EDAT- 2006/05/02 09:00
MHDA- 2011/04/13 06:00
CRDT- 2006/05/02 09:00
PHST- 2006/05/02 09:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
PHST- 2006/05/02 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Feb;20(3):119-21.