PMID- 16647010
OWN - NLM
STAT- MEDLINE
DCOM- 20100105
LR  - 20060501
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 18
IP  - 4
DP  - 2006 Apr
TI  - [Comparative study on characteristics of congestive heart failure patients with 
      preserved versus abnormal left ventricular systolic function and evaluation 
      effects of therapy].
PG  - 210-5
AB  - OBJECTIVE: To compare clinical characteristics and effects of therapy for 
      hospitalized patients with congestive heart failure (CHF) and different left 
      ventricular ejection fraction (LVEF) during hospitalization. METHODS: The medical 
      records of 1 074 unselected consecutive patients with CHF who were admitted to 
      Queen Mary Hospital from January, 2001 to January, 2002 were retrospectively 
      reviewed. Three hundred and ninety-nine patients were categorized as having 
      either normal left ventricular systolic function or systolic dysfunction based on 
      the results of echocardiography. Clinical features with a slightly modified 
      version of the Framingham criteria, laboratory results and drug therapies at 
      discharge were compared. RESULTS: Among patients, the majority were women, 95.5% 
      were > or =65 years and 50.6% > or =80 years of age. Classification of the 
      severity of heart failure showed that 70.2% were New York Heart Association 
      (NYHA) III and IV. Only 399 patients had borderline LVEF at the time of 
      hospitalization, of these patients 191 (47.9%) had preserved systolic function 
      (LVEF > or =0.50), and 208 (52.1%) with LVEF<0.50. Patients with LVEF > or =0.50, 
      who tended to be elderly and more often female, exhibited a lower incidence of 
      coronary artery disease and diabetes than patients with LVEF<0.50 (all P<0.05). 
      Patients with preserved systolic function had a significantly higher prevalence 
      of auricular fibrillation (P<0.05), accounting for up to 84 patients (44.0%) with 
      it, and number of hospitalization for CHF increased. Among patients with systolic 
      dysfunction, 22.6% were discharged on a therapeutic regimen of digoxin, 63.0% on 
      an angiotensin-converting enzyme inhibitor (ACEI), and 12.0% on a beta-blocker, 
      13.9% on a calcium channel blocker. These accounted for 62.3%, 35.1%, 9.4% and 
      18.3% in patients with preserved systolic function, respectively. There was a 
      higher incidence of use of digoxin (P<0.05). CONCLUSION: In hospitalized patients 
      with heart failure, the clinical signs and symptoms of chronic heart failure are 
      similar to those of patients with CHF, LVEF is a powerful prognostic predictor to 
      distinguish CHF patients with normal systolic function from those with systolic 
      dysfunction. Criteria for use of ACEI and beta-blocker are still not clear cut. 
      It is important to differentiate CHF patients with LVEF<0.50 from that with LVEF> 
      or =0.50 in order to achieve a better therapeutic result in the treatment of CHF.
FAU - Zhan, Hong
AU  - Zhan H
AD  - Department of Emergency, The First Affiliated Hospital to Zhongshan University, 
      Guangzhou 510080, Guangdong, China.
FAU - Tse, Hung-fat
AU  - Tse HF
FAU - Cao, Jing-ming
AU  - Cao JM
FAU - Lau, Cpu-pak
AU  - Lau CP
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Failure/complications/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume/*physiology
MH  - *Ventricular Function, Left
EDAT- 2006/05/02 09:00
MHDA- 2010/01/06 06:00
CRDT- 2006/05/02 09:00
PHST- 2006/05/02 09:00 [pubmed]
PHST- 2010/01/06 06:00 [medline]
PHST- 2006/05/02 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Apr;18(4):210-5.