PMID- 16647411
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20061115
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 148
IP  - 4
DP  - 2006 Apr
TI  - Single dose of anti-D immune globulin at 75 microg/kg is as effective as 
      intravenous immune globulin at rapidly raising the platelet count in newly 
      diagnosed immune thrombocytopenic purpura in children.
PG  - 489-94
AB  - OBJECTIVE: To conduct a randomized prospective trial of immune globulin treatment 
      for 105 Rh+ children with newly-diagnosed immune thrombocytopenic purpura and a 
      platelet count<20,000/microL, to determine whether anti-D immune globulin 
      (anti-D) is as effective as intravenous immune globulin (IVIg). STUDY DESIGN: 
      Eligible patients received either a single intravenous dose of 50 microg/kg 
      anti-D (anti-D50), 75 microg/kg anti-D, (anti-D75), or 0.8 g/kg IVIg, (IVIg). 
      Patients were monitored for response to treatment and adverse events. RESULTS: By 
      24 hours after treatment 50%, 72%, and 77% of patients in the anti-D50, anti-D75, 
      and IVIg groups, respectively, had achieved a platelet count>20,000/microL 
      (P=.03). By day 7, hemoglobin concentrations decreased by 1.6 g/dL, 2 g/dL, and 
      0.3 g/dL in the anti-D50, anti-D75, and IVIg groups, respectively. Headache, 
      fever, or chills occurred least often in the anti-D50 group. CONCLUSIONS: A 
      single 75 microg/kg dose of Anti-D raised the platelet count in children with 
      newly diagnosed immune thrombocytopenic purpura more rapidly than standard-dose 
      anti-D and as effectively as IVIg, with an acceptable safety profile.
FAU - Tarantino, Michael D
AU  - Tarantino MD
AD  - Comprehensive Bleeding Disorders Center, University of Illinois College of 
      Medicine, Peoria, Illinois 61614, and Children's Hospital of Orange County, 
      Orange, California, USA. mdtara@hemophilia-ctr-peoria.com
FAU - Young, Guy
AU  - Young G
FAU - Bertolone, Salvatore J
AU  - Bertolone SJ
FAU - Kalinyak, Karen A
AU  - Kalinyak KA
FAU - Shafer, Frank E
AU  - Shafer FE
FAU - Kulkarni, Roshni
AU  - Kulkarni R
FAU - Weber, Lisa C
AU  - Weber LC
FAU - Davis, Mary L
AU  - Davis ML
FAU - Lynn, Henry
AU  - Lynn H
FAU - Nugent, Diane J
AU  - Nugent DJ
CN  - Acute ITP Study Group
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
RN  - 0 (Rho(D) Immune Globulin)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Immunologic Factors/*administration & dosage/adverse effects/pharmacology
MH  - Infant
MH  - Male
MH  - Platelet Count
MH  - Prospective Studies
MH  - Purpura, Thrombocytopenic, Idiopathic/blood/*drug therapy
MH  - Rho(D) Immune Globulin/*administration & dosage/adverse effects/pharmacology
EDAT- 2006/05/02 09:00
MHDA- 2006/06/14 09:00
CRDT- 2006/05/02 09:00
PHST- 2005/04/21 00:00 [received]
PHST- 2005/10/25 00:00 [revised]
PHST- 2005/11/03 00:00 [accepted]
PHST- 2006/05/02 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/05/02 09:00 [entrez]
AID - S0022-3476(05)01089-9 [pii]
AID - 10.1016/j.jpeds.2005.11.019 [doi]
PST - ppublish
SO  - J Pediatr. 2006 Apr;148(4):489-94. doi: 10.1016/j.jpeds.2005.11.019.