PMID- 16647794
OWN - NLM
STAT- MEDLINE
DCOM- 20061031
LR  - 20191210
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 30
IP  - 7
DP  - 2006 Sep 30
TI  - Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women.
PG  - 1256-60
AB  - Neuroplastic processes are thought to be involved in the pathophysiology of many 
      psychiatric disorders, including major depression. It has been hypothesized that 
      the brain-derived neurotrophic factor (BNDF), a key factor in neuroplasticity, is 
      associated with depressive disorders. Our study evaluated the pre- and 
      post-treatment levels of BDNF in a group of depressed patients and compared them 
      with healthy controls. In order to exclude the effects of gender on 
      neuroplasticity, our study group was restricted to women exclusively and 
      consisted of 20 depressive patients and 20 healthy controls, with similar age and 
      educational level distribution. Blood samples were collected before the treatment 
      and on the sixth week of the treatment with 10 mg S-citalopram. The pre-treatment 
      BDNF levels of the depressed patients were found to be lower than those of the 
      healthy subjects. During the sixth week, the BDNF levels of depressive patients 
      were significantly higher than the pre-treatment levels but similar to those of 
      control subjects. These findings suggest that BDNF level may be an important 
      factor in the etiopathogenesis of depression and may have a role in the action 
      mechanism of antidepressant drugs.
FAU - Aydemir, Cigdem
AU  - Aydemir C
AD  - Ankara Numune Research and Education Hospital, Department of Psychiatry, Turkey. 
      aydemircigdem@yahoo.com <aydemircigdem@yahoo.com>
FAU - Yalcin, Esra Suer
AU  - Yalcin ES
FAU - Aksaray, Sabahat
AU  - Aksaray S
FAU - Kisa, Cebrail
AU  - Kisa C
FAU - Yildirim, Sema Gulen
AU  - Yildirim SG
FAU - Uzbay, Tayfun
AU  - Uzbay T
FAU - Goka, Erol
AU  - Goka E
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20060502
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0DHU5B8D6V (Citalopram)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antidepressive Agents, Second-Generation/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Citalopram/therapeutic use
MH  - Depression/*blood/drug therapy
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Statistics, Nonparametric
MH  - Time Factors
EDAT- 2006/05/02 09:00
MHDA- 2006/11/01 09:00
CRDT- 2006/05/02 09:00
PHST- 2006/05/02 09:00 [pubmed]
PHST- 2006/11/01 09:00 [medline]
PHST- 2006/05/02 09:00 [entrez]
AID - S0278-5846(06)00107-2 [pii]
AID - 10.1016/j.pnpbp.2006.03.025 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1256-60. doi: 
      10.1016/j.pnpbp.2006.03.025. Epub 2006 May 2.