PMID- 16649559
OWN - NLM
STAT- MEDLINE
DCOM- 20060530
LR  - 20181201
IS  - 0031-7144 (Print)
IS  - 0031-7144 (Linking)
VI  - 61
IP  - 4
DP  - 2006 Apr
TI  - Pluronic F127 gel effectively controls the burst release of drug from PLGA 
      microspheres.
PG  - 367-8
AB  - To investigate the controlled release effect of a thermo-sensitive gel, Pluronic 
      F127 (PF127) on microspheres, poly[D,L-lactic-co-glycolic acid] (PLGA) 
      microspheres were coated with Pluronic F127 gel and the in vitro release was 
      evaluated. The results demonstrated that PF127, which gelled at 37 degrees C, 
      inhibited the initial burst release of drug from microspheres effectively.
FAU - Wang, Y
AU  - Wang Y
AD  - Colege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, PR China.
FAU - Gao, J Q
AU  - Gao JQ
FAU - Chen, H L
AU  - Chen HL
FAU - Zheng, C H
AU  - Zheng CH
FAU - Liang, W Q
AU  - Liang WQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Pharmazie
JT  - Die Pharmazie
JID - 9800766
RN  - 0 (Excipients)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Polymers)
RN  - 106392-12-5 (Poloxamer)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Chemistry, Pharmaceutical
MH  - *Drug Delivery Systems
MH  - *Excipients
MH  - Hydrogen-Ion Concentration
MH  - Lactic Acid/*chemistry
MH  - Membranes, Artificial
MH  - Microspheres
MH  - *Poloxamer
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
EDAT- 2006/05/03 09:00
MHDA- 2006/05/31 09:00
CRDT- 2006/05/03 09:00
PHST- 2006/05/03 09:00 [pubmed]
PHST- 2006/05/31 09:00 [medline]
PHST- 2006/05/03 09:00 [entrez]
PST - ppublish
SO  - Pharmazie. 2006 Apr;61(4):367-8.