PMID- 16650175 OWN - NLM STAT- MEDLINE DCOM- 20061020 LR - 20151119 IS - 0011-9059 (Print) IS - 0011-9059 (Linking) VI - 45 IP - 4 DP - 2006 Apr TI - Cutaneous T-cell lymphoma with HTLV-I infection: clinical overlap with adult T-cell leukemia/lymphoma. PG - 447-9 AB - Adult T-cell leukemia/lymphoma (ATLL) is a malignant proliferation of mature helper T lymphocytes,(1) and is caused by human T-lymphotropic virus type I (HTLV-I);(2) an HTLV-I infection endemic in the Caribbean, south-western Japan, South America and Africa.(3,4) Seroepidemiological studies suggest that it is also endemic in Brazil.(5) Although carriers of HTLV-I show polyclonal integration of virus in T lymphocytes, only patients with ATLL of various subtypes show monoclonal integration of HTLV-I in tumor cells.(6,7) Cutaneous T-cell lymphomas (CTCL) are a group of primary cutaneous lymphoproliferative diseases(8) with unknown etiology.(9) The two most common presentations of CTCL are mycosis fungoides (MF) and Sezary syndrome (SS).(10-13) However, both CTCL categories can easily resemble ATLL. Therefore, in HTLV-I endemic areas, differentiation between ATLL and CTCL must be performed, as they have different prognoses and treatment approaches.(14). FAU - Sakamoto, F H AU - Sakamoto FH AD - Department of Dermatology, Discipline of Hematology and Hemotherapy, Universidade Federal de Sao Paulo -, Brazil. FAU - Colleoni, G W B AU - Colleoni GW FAU - Teixeira, S P AU - Teixeira SP FAU - Yamamoto, M AU - Yamamoto M FAU - Michalany, N S AU - Michalany NS FAU - Almeida, F A AU - Almeida FA FAU - Chiba, A K AU - Chiba AK FAU - Petri, V AU - Petri V FAU - Fernandes, M A AU - Fernandes MA FAU - Pombo-de-Oliveira, M S AU - Pombo-de-Oliveira MS LA - eng PT - Case Reports PT - Journal Article PL - England TA - Int J Dermatol JT - International journal of dermatology JID - 0243704 RN - 0 (Antineoplastic Agents) RN - 0 (DNA, Viral) RN - 0 (Interferon-alpha) RN - 4B9XT59T7S (Zidovudine) RN - 5J49Q6B70F (Vincristine) RN - 80168379AG (Doxorubicin) RN - 8N3DW7272P (Cyclophosphamide) RN - VB0R961HZT (Prednisone) RN - CHOP protocol SB - IM MH - Adult MH - Antineoplastic Agents/therapeutic use MH - Antineoplastic Combined Chemotherapy Protocols/therapeutic use MH - Brazil MH - Cyclophosphamide/therapeutic use MH - DNA, Viral/analysis MH - Doxorubicin/therapeutic use MH - Endemic Diseases MH - Humans MH - Interferon-alpha/therapeutic use MH - Leukemia-Lymphoma, Adult T-Cell/*diagnosis/drug therapy MH - Male MH - Neoplasm Recurrence, Local MH - Polymerase Chain Reaction MH - Prednisone/therapeutic use MH - Vincristine/therapeutic use MH - Zidovudine/therapeutic use EDAT- 2006/05/03 09:00 MHDA- 2006/10/21 09:00 CRDT- 2006/05/03 09:00 PHST- 2006/05/03 09:00 [pubmed] PHST- 2006/10/21 09:00 [medline] PHST- 2006/05/03 09:00 [entrez] AID - IJD2687 [pii] AID - 10.1111/j.1365-4632.2006.02687.x [doi] PST - ppublish SO - Int J Dermatol. 2006 Apr;45(4):447-9. doi: 10.1111/j.1365-4632.2006.02687.x.