PMID- 16651450
OWN - NLM
STAT- MEDLINE
DCOM- 20060705
LR  - 20191210
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 66
IP  - 9
DP  - 2006 May 1
TI  - Menin links estrogen receptor activation to histone H3K4 trimethylation.
PG  - 4929-35
AB  - The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor 
      gene, menin, is an integral component of MLL1/MLL2 histone methyltransferase 
      complexes specific for Lys4 of histone H3 (H3K4). We show that menin is a 
      transcriptional coactivator of the nuclear receptors for estrogen and vitamin D. 
      Activation of the endogenous estrogen-responsive TFF1 (pS2) gene results in 
      promoter recruitment of menin and in elevated trimethylation of H3K4. Knockdown 
      of menin reduces both activated TFF1 (pS2) transcription and H3K4 trimethylation. 
      In addition, menin can directly interact with the estrogen receptor-alpha 
      (ERalpha) in a hormone-dependent manner. The majority of disease-related MEN1 
      mutations prevent menin-ERalpha interaction. Importantly, ERalpha-interacting 
      mutants are also defective in coactivator function. Our results indicate that 
      menin is a critical link between recruitment of histone methyltransferase 
      complexes and nuclear receptor-mediated transcription.
FAU - Dreijerink, Koen M A
AU  - Dreijerink KM
AD  - Departments of Physiological Chemistry, University Medical Center Utrecht, 
      Utrecht, the Netherlands.
FAU - Mulder, Klaas W
AU  - Mulder KW
FAU - Winkler, G Sebastiaan
AU  - Winkler GS
FAU - Hoppener, Jo W M
AU  - Hoppener JW
FAU - Lips, Cornelis J M
AU  - Lips CJ
FAU - Timmers, H Th Marc
AU  - Timmers HT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Histones)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (TFF1 protein, human)
RN  - 0 (Trefoil Factor-1)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Animals
MH  - COS Cells
MH  - Chlorocebus aethiops
MH  - DNA Methylation
MH  - Estrogen Receptor alpha/*metabolism
MH  - Gene Expression
MH  - Histones/genetics/*metabolism
MH  - Humans
MH  - Mutation
MH  - Promoter Regions, Genetic
MH  - Proto-Oncogene Proteins/*genetics/metabolism
MH  - Transcriptional Activation/*physiology
MH  - Trefoil Factor-1
MH  - Tumor Suppressor Proteins/biosynthesis/genetics
EDAT- 2006/05/03 09:00
MHDA- 2006/07/06 09:00
CRDT- 2006/05/03 09:00
PHST- 2006/05/03 09:00 [pubmed]
PHST- 2006/07/06 09:00 [medline]
PHST- 2006/05/03 09:00 [entrez]
AID - 66/9/4929 [pii]
AID - 10.1158/0008-5472.CAN-05-4461 [doi]
PST - ppublish
SO  - Cancer Res. 2006 May 1;66(9):4929-35. doi: 10.1158/0008-5472.CAN-05-4461.