PMID- 16651766
OWN - NLM
STAT- MEDLINE
DCOM- 20060705
LR  - 20190706
IS  - 0009-2363 (Print)
IS  - 0009-2363 (Linking)
VI  - 54
IP  - 5
DP  - 2006 May
TI  - HIV-1 integrase inhibition of biscoumarin analogues.
PG  - 682-6
AB  - Nineteen biscoumarins bearing free and modified hydroxyl substituents at 
      benzoyloxyphenyl linker have been synthesized by multiple step synthesis. Among 
      these biscoumarins, thirteen were found to be active molecules against HIV-1 
      integrase (HIV-1 IN). The structure-activity relationship of the nineteen 
      compounds on HIV IN may be useful for the design of potent therapeutic agents.
FAU - Su, Chang-Xiao
AU  - Su CX
AD  - School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan, ROC.
FAU - Mouscadet, Jean-Francois
AU  - Mouscadet JF
FAU - Chiang, Chih-Chia
AU  - Chiang CC
FAU - Tsai, Hou-Jen
AU  - Tsai HJ
FAU - Hsu, Ling-Yih
AU  - Hsu LY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Coumarins)
RN  - 0 (Flavonoids)
RN  - 0 (HIV Integrase Inhibitors)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Oligonucleotides)
RN  - 0 (Phenols)
RN  - 0 (Polyphenols)
RN  - 73Y7P0K73Y (Thioctic Acid)
SB  - IM
MH  - Acetylation
MH  - Coumarins/*chemical synthesis/*pharmacology
MH  - Flavonoids/chemistry
MH  - HIV Integrase Inhibitors/*chemical synthesis/*pharmacology
MH  - HIV-1/drug effects/*enzymology
MH  - Hydrolysis
MH  - Hydroxylation
MH  - Indicators and Reagents
MH  - Magnetic Resonance Spectroscopy
MH  - Oligonucleotides/chemical synthesis/pharmacology
MH  - Phenols/chemistry
MH  - Polyphenols
MH  - Spectrometry, Mass, Fast Atom Bombardment
MH  - Structure-Activity Relationship
MH  - Thioctic Acid/chemistry
EDAT- 2006/05/03 09:00
MHDA- 2006/07/06 09:00
CRDT- 2006/05/03 09:00
PHST- 2006/05/03 09:00 [pubmed]
PHST- 2006/07/06 09:00 [medline]
PHST- 2006/05/03 09:00 [entrez]
AID - JST.JSTAGE/cpb/54.682 [pii]
AID - 10.1248/cpb.54.682 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2006 May;54(5):682-6. doi: 10.1248/cpb.54.682.