PMID- 1665382
OWN - NLM
STAT- MEDLINE
DCOM- 19920408
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 559
IP  - 2
DP  - 1991 Sep 20
TI  - Separation of periventricular dopaminergic and alpha-adrenergic systems from the 
      vasopressin-secreting mechanisms activated by prostaglandin D2.
PG  - 261-6
AB  - The aim of this study was to evaluate periventricular dopaminergic and 
      alpha-adrenergic receptor functions in vasopressin (AVP) secretion elicited by 
      central applications of prostaglandin D2 (PGD2) in conscious rats. 
      Intracerebroventricular (i.c.v.) injections of PGD2 (70.9 nmol (25.0 micrograms] 
      produced transient rises in plasma AVP 5 min later, without increasing plasma 
      osmolality, sodium and hematocrit. Arterial pressure and heart rate before and 
      after the PGD2 administrations were not significantly different from those of 
      control rats receiving its vehicle. The PGD2-induced AVP response was not 
      significantly altered by the prior i.c.v. administrations (0.15 mumol) of 
      dopamine receptor antagonists, SCH 23390 or sulpiride, and an 
      alpha-adrenoreceptor antagonist, phenoxybenzamine, performed 10 min before the 
      injections of PGD2. The pretreatments with these catecholamine antagonists were 
      confirmed to significantly prevent the augmentations in plasma AVP 5 min after 
      the i.c.v. applications of 0.75 mumol dopamine or phenylephrine that were 
      considerably larger than the PGD 2-induced AVP response. From these results, we 
      concluded that dopaminergic and alpha-adrenergic receptors in the periventricular 
      regions may not be involved in the AVP secretion stimulated by PGD2.
FAU - Yamaguchi, K
AU  - Yamaguchi K
AD  - Department of Physiology, Niigata University School of Medicine, Japan.
FAU - Hama, H
AU  - Hama H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Benzazepines)
RN  - 0 (Electrolytes)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 0TTZ664R7Z (Phenoxybenzamine)
RN  - 11000-17-2 (Vasopressins)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 7MNE9M8287 (Sulpiride)
RN  - RXY07S6CZ2 (Prostaglandin D2)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Benzazepines/administration & dosage/pharmacology
MH  - Cerebral Ventricles/*physiology
MH  - Dopamine/administration & dosage/pharmacology/*physiology
MH  - Electrolytes/blood
MH  - Hematocrit
MH  - Injections, Intraventricular
MH  - Male
MH  - Phenoxybenzamine/administration & dosage/pharmacology
MH  - Phenylephrine/pharmacology
MH  - Prostaglandin D2/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Adrenergic, alpha/*physiology
MH  - Sulpiride/administration & dosage/pharmacology
MH  - Vasopressins/*metabolism
EDAT- 1991/09/20 00:00
MHDA- 1991/09/20 00:01
CRDT- 1991/09/20 00:00
PHST- 1991/09/20 00:00 [pubmed]
PHST- 1991/09/20 00:01 [medline]
PHST- 1991/09/20 00:00 [entrez]
AID - 0006-8993(91)90010-S [pii]
AID - 10.1016/0006-8993(91)90010-s [doi]
PST - ppublish
SO  - Brain Res. 1991 Sep 20;559(2):261-6. doi: 10.1016/0006-8993(91)90010-s.