PMID- 16669409
OWN - NLM
STAT- MEDLINE
DCOM- 20060823
LR  - 20170214
IS  - 1358-863X (Print)
IS  - 1358-863X (Linking)
VI  - 11
IP  - 1
DP  - 2006 Feb
TI  - Markers of vascular inflammation are associated with the extent of 
      atherosclerosis assessed as angiographic score and treadmill walking distances in 
      patients with peripheral arterial occlusive disease.
PG  - 21-8
AB  - The importance of inflammation in atherosclerosis is well established in 
      cardiovascular disease. However, limited data exist on the relationship between 
      vascular inflammation and the severity of peripheral arterial occlusive disease 
      (PAD). We investigated the relationship between biochemical markers of vascular 
      inflammation and the diagnostic measures of PAD: ankle-brachial pressure index 
      (ABI), maximum treadmill walking distance and angiographic score. In 127 patients 
      (mean age 66 years; 64% males) with angiographically verified PAD, fasting blood 
      samples were drawn for determination of selected soluble cell adhesion molecules, 
      cytokines and chemokines. Tumor necrosis factor-alpha (TNFalpha), interleukin-6 
      (IL-6), monocyte chemoattractant protein-1 (MCP-1) and CD40 ligand (CD40L) were 
      all significantly correlated with the angiographic score (p < 0.05 for all). 
      After adjustment for relevant co-variates, MCP-1 and CD40L remained statistically 
      significant (p < 0.01 for both). IL-6 was, independent of other risk factors, 
      inversely correlated with the maximum treadmill walking distance (p < 0.01). Our 
      cross-sectional study in PAD patients showed that the vascular inflammatory 
      markers MCP-1, CD40L and IL-6 were significantly associated with the extent of 
      atherosclerosis, assessed by angiographic score and maximum treadmill walking 
      distance. These findings indicate that vascular inflammation is implicated in 
      PAD, which might be of importance in future diagnosis and treatment of the 
      disease.
FAU - Nylaende, M
AU  - Nylaende M
AD  - Departments of Vascular Surgery, Aker University Hospital, Oslo, Norway. 
      marthe@nylaende.com
FAU - Kroese, A
AU  - Kroese A
FAU - Stranden, E
AU  - Stranden E
FAU - Morken, B
AU  - Morken B
FAU - Sandbaek, G
AU  - Sandbaek G
FAU - Lindahl, A K
AU  - Lindahl AK
FAU - Arnesen, H
AU  - Arnesen H
FAU - Seljeflot, I
AU  - Seljeflot I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Vasc Med
JT  - Vascular medicine (London, England)
JID - 9610930
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Aged
MH  - Ankle/blood supply
MH  - Atherosclerosis/*blood/diagnostic imaging/physiopathology
MH  - *Blood Pressure
MH  - Brachial Artery/physiopathology
MH  - CD40 Ligand/*blood
MH  - Chemokine CCL2/*blood
MH  - Cross-Sectional Studies
MH  - *Exercise Test
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/*blood/diagnostic imaging/physiopathology
MH  - Radiography
MH  - Severity of Illness Index
MH  - Vasculitis/*blood/diagnostic imaging/physiopathology
MH  - *Walking
EDAT- 2006/05/04 09:00
MHDA- 2006/08/24 09:00
CRDT- 2006/05/04 09:00
PHST- 2006/05/04 09:00 [pubmed]
PHST- 2006/08/24 09:00 [medline]
PHST- 2006/05/04 09:00 [entrez]
AID - 10.1191/1358863x06vm662oa [doi]
PST - ppublish
SO  - Vasc Med. 2006 Feb;11(1):21-8. doi: 10.1191/1358863x06vm662oa.