PMID- 16671867
OWN - NLM
STAT- MEDLINE
DCOM- 20060719
LR  - 20081121
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 77
IP  - 5
DP  - 2006 May
TI  - The effect of varying the particle size of beta tricalcium phosphate carrier of 
      recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial 
      defects.
PG  - 765-72
AB  - BACKGROUND: Beta tricalcium phosphate (beta-TCP) has been developed as one of the 
      carriers of recombinant human bone morphogenetic protein (rhBMP). However, it is 
      not known whether the particle size of beta-TCP is related to its resorption rate 
      and the degree of bone formation. The purpose of this study was to evaluate the 
      effect of using beta-TCP with different particle sizes on the ability of rhBMP-4 
      to enhance bone formation in the rat calvarial defect model. METHODS: Calvarial, 
      8-mm-diameter, critical-size defects were created in 100 male Sprague-Dawley 
      rats. Five groups of 20 animals each received either rhBMP-4 (2.5 microg) using 
      beta-TCP with a particle size of 50 to 150 microm, rhBMP-4 (2.5 microg) using 
      beta-TCP with a particle size of 150 to 500 microm, a beta-TCP control with a 
      particle size of 50 to 150 microm, a beta-TCP control with a particle size of 150 
      to 500 microm, or a sham-surgery control, respectively, and were evaluated by 
      measuring their histologic and histometric parameters following a 2- and 8-week 
      healing interval. RESULTS: There were no significant differences in the defect 
      closure, new bone area, or augmented area between either the two rhBMP-4/beta-TCP 
      groups or between the two beta-TCP control groups at 2 and 8 weeks. CONCLUSIONS: 
      rhBMP-4 combined with either small- or large-particle beta-TCP had a significant 
      effect on the induction of bone formation compared to either a small- or 
      large-particle beta-TCP control or a sham-surgery control. Within the parameters 
      of this study, varying the particle size of beta-TCP did not seem to have a 
      significant effect on bone formation.
FAU - Jung, Ui-Won
AU  - Jung UW
AD  - Department of Periodontology, Research Institute for Periodontal Regeneration, 
      College of Dentistry, Yonsei University, Seoul, Korea.
FAU - Choi, Seong-Yong
AU  - Choi SY
FAU - Pang, Eun-Kyoung
AU  - Pang EK
FAU - Kim, Chang-Sung
AU  - Kim CS
FAU - Choi, Seong-Ho
AU  - Choi SH
FAU - Cho, Kyoo-Sung
AU  - Cho KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (BMP4 protein, human)
RN  - 0 (Bmp4 protein, rat)
RN  - 0 (Bone Morphogenetic Protein 4)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Drug Carriers)
RN  - 0 (Recombinant Proteins)
RN  - 0 (beta-tricalcium phosphate)
SB  - IM
MH  - Animals
MH  - Bone Morphogenetic Protein 4
MH  - Bone Morphogenetic Proteins/*therapeutic use
MH  - *Bone Regeneration
MH  - Bone Substitutes/chemistry/*therapeutic use
MH  - Calcium Phosphates/chemistry/*therapeutic use
MH  - Drug Carriers/*chemistry
MH  - Humans
MH  - Male
MH  - Particle Size
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recombinant Proteins/therapeutic use
MH  - Skull/*surgery
EDAT- 2006/05/05 09:00
MHDA- 2006/07/20 09:00
CRDT- 2006/05/05 09:00
PHST- 2006/05/05 09:00 [pubmed]
PHST- 2006/07/20 09:00 [medline]
PHST- 2006/05/05 09:00 [entrez]
AID - 10.1902/jop.2006.050268 [doi]
PST - ppublish
SO  - J Periodontol. 2006 May;77(5):765-72. doi: 10.1902/jop.2006.050268.