PMID- 1667201
OWN - NLM
STAT- MEDLINE
DCOM- 19920527
LR  - 20131121
IS  - 0023-6764 (Print)
IS  - 0023-6764 (Linking)
VI  - 41
IP  - 6
DP  - 1991 Dec
TI  - Abnormal renal response to twenty-four-hour dehydration and fasting in Nagase 
      analbuminemic rats.
PG  - 577-80
AB  - We assessed renal function in fasting adult Nagase analbuminemic rats (NAR). 
      Sodium output in male and female NAR was 68% and 46%, respectively, of the output 
      of age- and sex-matched normal Sprague-Dawley (SD) rats. Potassium excretion was 
      significantly greater in female NAR but there was no difference between male NAR 
      and SD rats. The renal clearances of urea and creatinine were reduced in NAR with 
      corresponding increases in plasma concentrations; however, the urea and 
      creatinine concentrations were not different in plasma samples taken from 
      normally fed and hydrated SD and NAR rats. Exchangeable body sodium and sodium 
      space was significantly larger in normally fed and hydrated NAR than in SD but 
      there were no differences in plasma sodium concentrations or plasma volumes. 
      Although plasma concentrations of albumin in NAR were only about 0.07% of the 
      concentration in SD rats, the renal clearance of albumin in NAR was threefold 
      greater. Kidney weights in NAR were 10 to 16% less than in SD rats but liver 
      weights were 22 to 42% greater. Clearly, renal function was markedly abnormal in 
      Nagase rats during a 24-hour fast.
FAU - Yaschuk, D M
AU  - Yaschuk DM
AD  - Department of Physiology, Faculty of Medicine, University of British Columbia, 
      Vancouver, Canada.
FAU - Sanker, J M
AU  - Sanker JM
FAU - Zhou, J
AU  - Zhou J
FAU - Wilson, N
AU  - Wilson N
FAU - Keeler, R
AU  - Keeler R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lab Anim Sci
JT  - Laboratory animal science
JID - 1266503
RN  - 0 (Serum Albumin)
RN  - 8W8T17847W (Urea)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Animals
MH  - Blood Volume
MH  - Creatinine/metabolism
MH  - Dehydration/physiopathology
MH  - Fasting/physiology
MH  - Female
MH  - Kidney/*physiopathology
MH  - Male
MH  - Natriuresis
MH  - Plasma Volume
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rats, Mutant Strains/*physiology
MH  - Serum Albumin/*deficiency
MH  - Urea/metabolism
EDAT- 1991/12/01 00:00
MHDA- 1991/12/01 00:01
CRDT- 1991/12/01 00:00
PHST- 1991/12/01 00:00 [pubmed]
PHST- 1991/12/01 00:01 [medline]
PHST- 1991/12/01 00:00 [entrez]
PST - ppublish
SO  - Lab Anim Sci. 1991 Dec;41(6):577-80.