PMID- 16672547
OWN - NLM
STAT- MEDLINE
DCOM- 20060718
LR  - 20181201
IS  - 1544-0737 (Electronic)
IS  - 0895-9374 (Linking)
VI  - 19
IP  - 1
DP  - 2006 Apr 1
TI  - Dendritic cells and HIV infection: activating dendritic cells to boost immunity.
PG  - 36-41
AB  - Dendritic cells (DCs) are white blood cells that coordinate innate and adaptive 
      immunity. They are distributed within epithelia and mucosal-associated lymphoid 
      tissues, positioned to entrap incoming pathogens or vaccines. Human 
      immunodeficiency virus (HIV) and the non-human primate equivalent (SIV) exploit 
      DCs to amplify infection, underscoring the need to harness strategies that 
      promote presentation of virus by DCs to stimulate potent anti-viral immunity 
      instead of virus transmission. Two main subsets of DCs need to be considered: 
      myeloid (MDC) and plasmacytoid (PDC) subsets. Using the SIV-macaque system to 
      advance oral vaccine research, we examined macaque PDC and MDC biology, 
      identifying ways to activate DCs and boost antiviral immunity. Immunostimulatory 
      oligodeoxyribonucleotides (ISS-ODNs) stimulated PDC/MDC mixtures to up-regulate 
      co-stimulatory molecule expression and to secrete both IFN-alpha and IL-12. 
      Additionally, ISS-ODNs augmented SIV-specific IFN-gamma responses induced by 
      virus-bearing DCs. ISS-ODN-driven DC activation is being pursued to improve 
      oral/nasopharyngeal mucosal vaccines and therapies against HIV.
FAU - Teleshova, N
AU  - Teleshova N
AD  - Center for Biomedical Research, Population Council, 1230 York Avenue, New York, 
      NY 10021, USA.
FAU - Kenney, J
AU  - Kenney J
FAU - Robbiani, M
AU  - Robbiani M
LA  - eng
GR  - DE015512/DE/NIDCR NIH HHS/United States
GR  - DE016256/DE/NIDCR NIH HHS/United States
GR  - DE016534/DE/NIDCR NIH HHS/United States
GR  - HD041752/HD/NICHD NIH HHS/United States
GR  - P01S AI052048/AI/NIAID NIH HHS/United States
GR  - R01S AI040877/AI/NIAID NIH HHS/United States
GR  - R21S AI060405/AI/NIAID NIH HHS/United States
GR  - RR00164/RR/NCRR NIH HHS/United States
GR  - U19 AI065413/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060401
PL  - United States
TA  - Adv Dent Res
JT  - Advances in dental research
JID - 8802131
RN  - 0 (AIDS Vaccines)
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (C274 oligonucleotide)
RN  - 0 (Interferon-alpha)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Oligonucleotides)
RN  - 0 (SAIDS Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
MH  - *AIDS Vaccines
MH  - Adjuvants, Immunologic/*pharmacology
MH  - Animals
MH  - Dendritic Cells/drug effects/*immunology/*virology
MH  - HIV Infections/*immunology/transmission
MH  - Humans
MH  - Immunity, Mucosal/drug effects/physiology
MH  - Interferon-alpha/metabolism
MH  - Interferon-gamma/metabolism
MH  - Lymphocyte Activation
MH  - Macaca
MH  - Oligodeoxyribonucleotides/*pharmacology
MH  - Oligonucleotides/pharmacology
MH  - SAIDS Vaccines
MH  - Simian Immunodeficiency Virus/physiology
EDAT- 2006/05/05 09:00
MHDA- 2006/07/19 09:00
CRDT- 2006/05/05 09:00
PHST- 2006/05/05 09:00 [pubmed]
PHST- 2006/07/19 09:00 [medline]
PHST- 2006/05/05 09:00 [entrez]
AID - 19/1/36 [pii]
AID - 10.1177/154407370601900108 [doi]
PST - epublish
SO  - Adv Dent Res. 2006 Apr 1;19(1):36-41. doi: 10.1177/154407370601900108.