PMID- 16674832
OWN - NLM
STAT- MEDLINE
DCOM- 20060711
LR  - 20221207
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 5
DP  - 2006 May 5
TI  - Xenoestrogenic activity in blood of European and Inuit populations.
PG  - 12
AB  - BACKGROUND: Human exposure to persistent organic pollutants (POPs) is ubiquitous 
      and found in all individuals. Studies have documented endocrine disrupting 
      effects and impact on reproduction. The aim of the present study was to compare 
      the level of xenoestrogenic activity in serum of groups with varying POP 
      exposure, and to evaluate correlations to the POP biomarkers, 
      2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis 
      (p-chlorophenyl)-ethylene (p,p'-DDE). METHODS: The study included 358 men: 
      Greenlandic Inuit's, Swedish fishermen, and Warsaw (Poland) and Kharkiv (Ukraine) 
      inhabitants. Xenoestrogenicity of serum extracts alone (XER) and XER competitive 
      (XERcomp) effect on 17beta-estradiol induced estrogen receptor (ER) transactivity 
      were assessed in the hormone free, lipophilic serum fraction containing the POPs 
      using the MVLN human breast cancer cell line. RESULTS: No agonistic XER activity 
      was exhibited for Inuit serum samples, while 12 - 24% of the European samples had 
      detectable agonistic XER activity. On the contrary, 71% of Inuit serum samples 
      antagonized XERcomp compared to 7 - 30 % in the other regions. XER and XERcomp 
      were not or weakly correlated to the two POP markers. XER activity of Inuit 
      samples was negatively associated to levels of CB-153 and p,p'-DDE. For the 
      Warsaw group a positive and negative correlation between XER and p,p'-DDE and 
      estradiol equivalence level and CB-153 levels was found. CONCLUSION: No strong 
      consistent association between xenoestrogenic net activity and the two POP 
      markers was found. The results showed that the selected POP markers alone can not 
      predict the integrated xenoestrogenic serum activity. Correlations to the POP 
      markers were found at the extreme edge; the Inuit's and Warsaw study groups 
      eliciting high frequency of samples with ER antagonistic and agonistic activity, 
      respectively. We suggest that the variation in xenoestrogenic serum activity 
      reflects differences in POP exposure mixture, genetic factors and/or life style 
      factors.
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
AD  - Unit of Cellular and Molecular Toxicology, Department of Environmental and 
      Occupational Medicine, Institute of Public Health, Vennelyst Boulevard 6, Build, 
      1260, University of Aarhus, DK-8000 Aarhus, Denmark. ebj@mil.au.dk
FAU - Hjelmborg, Philip S
AU  - Hjelmborg PS
FAU - Reinert, Thayaline S
AU  - Reinert TS
FAU - Andersen, Birgitte S
AU  - Andersen BS
FAU - Lesovoy, Vladimir
AU  - Lesovoy V
FAU - Lindh, Christian H
AU  - Lindh CH
FAU - Hagmar, Lars
AU  - Hagmar L
FAU - Giwercman, Aleksander
AU  - Giwercman A
FAU - Erlandsen, Mogens
AU  - Erlandsen M
FAU - Manicardi, Gian-Carlo
AU  - Manicardi GC
FAU - Spano, Marcello
AU  - Spano M
FAU - Toft, Gunnar
AU  - Toft G
FAU - Bonde, Jens Peter
AU  - Bonde JP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060505
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Biomarkers)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Estrogens)
RN  - 0 (Insecticides)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Xenobiotics)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4TI98Z838E (Estradiol)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biological Assay
MH  - Biomarkers/*blood
MH  - Breast Neoplasms/pathology
MH  - Cohort Studies
MH  - Dichlorodiphenyl Dichloroethylene/*blood/toxicity
MH  - Endocrine Disruptors/*toxicity
MH  - Environmental Exposure
MH  - Environmental Pollutants/*toxicity
MH  - Estradiol/physiology
MH  - Estrogens/blood/toxicity
MH  - Europe
MH  - Female
MH  - Humans
MH  - Insecticides/*blood/toxicity
MH  - *Inuit
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/*blood/toxicity
MH  - Receptors, Estrogen/drug effects
MH  - Tumor Cells, Cultured
MH  - White People
MH  - Xenobiotics/toxicity
PMC - PMC1481538
EDAT- 2006/05/06 09:00
MHDA- 2006/07/13 09:00
PMCR- 2006/05/05
CRDT- 2006/05/06 09:00
PHST- 2005/11/16 00:00 [received]
PHST- 2006/05/05 00:00 [accepted]
PHST- 2006/05/06 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2006/05/06 09:00 [entrez]
PHST- 2006/05/05 00:00 [pmc-release]
AID - 1476-069X-5-12 [pii]
AID - 10.1186/1476-069X-5-12 [doi]
PST - epublish
SO  - Environ Health. 2006 May 5;5:12. doi: 10.1186/1476-069X-5-12.