PMID- 16675100
OWN - NLM
STAT- MEDLINE
DCOM- 20070222
LR  - 20061218
IS  - 0303-2647 (Print)
IS  - 0303-2647 (Linking)
VI  - 87
IP  - 1
DP  - 2007 Jan
TI  - Sensitive dependence of the coefficient of variation of interspike intervals on 
      the lower boundary of membrane potential for the leaky integrate-and-fire neuron 
      model.
PG  - 49-57
AB  - After the report of Softky and Koch [Softky, W.R., Koch, C., 1993. The highly 
      irregular firing of cortical cells is inconsistent with temporal integration of 
      random EPSPs. J. Neurosci. 13, 334-350], leaky integrate-and-fire models have 
      been investigated to explain high coefficient of variation (CV) of interspike 
      intervals (ISIs) at high firing rates observed in the cortex. The purpose of this 
      paper is to study the effect of the position of a lower boundary of membrane 
      potential on the possible value of CV of ISIs based on the diffusional leaky 
      integrate-and-fire models with and without reversal potentials. Our result shows 
      that the irregularity of ISIs for the diffusional leaky integrate-and-fire neuron 
      significantly changes by imposing a lower boundary of membrane potential, which 
      suggests the importance of the position of the lower boundary as well as that of 
      the firing threshold when we study the statistical properties of leaky 
      integrate-and-fire neuron models. It is worth pointing out that the mean-CV plot 
      of ISIs for the diffusional leaky integrate-and-fire neuron with reversal 
      potentials shows a close similarity to the experimental result obtained in Softky 
      and Koch [Softky, W.R., Koch, C., 1993. The highly irregular firing of cortical 
      cells is inconsistent with temporal integration of random EPSPs. J. Neurosci. 13, 
      334-350].
FAU - Inoue, Junko
AU  - Inoue J
AD  - Faculty of Human Relation, Kyoto Koka Women's University, Kyoto 615-0882, Japan. 
      jdoi@mail.koka.ac.jp
FAU - Doi, Shinji
AU  - Doi S
LA  - eng
PT  - Journal Article
DEP - 20060314
PL  - Ireland
TA  - Biosystems
JT  - Bio Systems
JID - 0430773
SB  - IM
MH  - *Action Potentials
MH  - Models, Theoretical
MH  - Neurons/*physiology
EDAT- 2006/05/06 09:00
MHDA- 2007/02/23 09:00
CRDT- 2006/05/06 09:00
PHST- 2005/08/03 00:00 [received]
PHST- 2006/03/07 00:00 [revised]
PHST- 2006/03/07 00:00 [accepted]
PHST- 2006/05/06 09:00 [pubmed]
PHST- 2007/02/23 09:00 [medline]
PHST- 2006/05/06 09:00 [entrez]
AID - S0303-2647(06)00047-5 [pii]
AID - 10.1016/j.biosystems.2006.03.003 [doi]
PST - ppublish
SO  - Biosystems. 2007 Jan;87(1):49-57. doi: 10.1016/j.biosystems.2006.03.003. Epub 
      2006 Mar 14.