PMID- 16675263
OWN - NLM
STAT- MEDLINE
DCOM- 20070220
LR  - 20151119
IS  - 1010-7940 (Print)
IS  - 1010-7940 (Linking)
VI  - 29
IP  - 6
DP  - 2006 Jun
TI  - Expression of hypoxia-inducible factor-1 alpha and its prognostic significance in 
      small-sized adenocarcinomas of the lung.
PG  - 891-5
AB  - OBJECTIVE: To analyze the prognostic value of hypoxia-inducible factor-1 (HIF-1) 
      alpha expression and its correlation with clinicopathologic variables and the 
      expression of vascular endothelial growth factor-A and -C in patients with lung 
      adenocarcinomas of small size. METHODS: The expression of hypoxia-inducible 
      factor-1 alpha was immunohistochemically determined in 78 cases of small-sized 
      adenocarcinoma (maximum dimension < or = 2 cm) using antibody against a 
      recombinant protein corresponding to amino acids 575-780 of hypoxia-inducible 
      factor-1 alpha. Data regarding patient survival, clinicopathologic factors, and 
      immunohistochemical studies of vascular endothelial growth factors were also 
      collected. RESULTS: Strong expression of hypoxia-inducible factor-1 alpha was 
      observed in 23 of 78 cases; absent or minimal expression was found in the 
      localized bronchioloalveolar carcinomas. Strong expression of hypoxia-inducible 
      factor-1 alpha was significantly higher in cases with vascular invasion, lymph 
      node involvement, and vascular endothelial growth factor-A expression. The 5-year 
      survival rate was 63.2% if expression of hypoxia-inducible factor-1 alpha was 
      strong and 85.1% if expression was weak (p < 0.05). CONCLUSION: 
      Immunohistochemical staining of HIF-1 alpha, along with examination of metastatic 
      potential via vascular pathways, may be valid defining a subpopulation of 
      patients with small-sized adenocarcinoma of the lung whose tumors have aggressive 
      angiogenesis potential.
FAU - Enatsu, Sotarou
AU  - Enatsu S
AD  - Second Department of Surgery, Faculty of Medicine, Fukuoka University, 7-45-1, 
      Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. md040004@cis.fukuoka-u.ac.jp
FAU - Iwasaki, Akinori
AU  - Iwasaki A
FAU - Shirakusa, Takayuki
AU  - Shirakusa T
FAU - Hamasaki, Makoto
AU  - Hamasaki M
FAU - Nabeshima, Kazuki
AU  - Nabeshima K
FAU - Iwasaki, Hiroshi
AU  - Iwasaki H
FAU - Kuroki, Motomu
AU  - Kuroki M
FAU - Kuroki, Masahide
AU  - Kuroki M
LA  - eng
PT  - Journal Article
DEP - 20060503
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factor C)
SB  - IM
MH  - Adenocarcinoma/*metabolism/pathology/secondary/surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - Lung Neoplasms/*metabolism/pathology/surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/metabolism
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - Vascular Endothelial Growth Factor C/metabolism
EDAT- 2006/05/06 09:00
MHDA- 2007/02/21 09:00
CRDT- 2006/05/06 09:00
PHST- 2006/01/06 00:00 [received]
PHST- 2006/03/09 00:00 [revised]
PHST- 2006/03/14 00:00 [accepted]
PHST- 2006/05/06 09:00 [pubmed]
PHST- 2007/02/21 09:00 [medline]
PHST- 2006/05/06 09:00 [entrez]
AID - S1010-7940(06)00296-X [pii]
AID - 10.1016/j.ejcts.2006.03.027 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2006 Jun;29(6):891-5. doi: 10.1016/j.ejcts.2006.03.027. 
      Epub 2006 May 3.