PMID- 16676057
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20061115
IS  - 0720-9355 (Print)
IS  - 0720-9355 (Linking)
VI  - 26
IP  - 2
DP  - 2006 May
TI  - [Acute coronary syndrome: peri-interventional antithrombotic therapy].
PG  - 138-46
AB  - In patients with acute coronary syndrome (ACS), the periinterventional 
      antithrombotic treatment has become increasingly important for the choice of 
      reperfusion strategy and as an adjunct pharmacological treatment prior, during 
      and after percutaneous coronary interventions (PCI). In NSTE-ACS and early 
      invasive strategy (<48 h), treatment with ASA, clopidogrel and heparin - 
      unfractionated heparin (UFH) preferred - should be initiated as soon as possible. 
      Direct thrombin inhibitors are an alternative to heparin, particularly in the 
      setting of increased risk of bleeding and heparin-induced thrombocytopenia. In 
      highrisk patients, an so-called upstream therapy with glycoprotein IIb/IIIa 
      inhibitors (tirofiban, eptifibatide) is recommended as an adjunct to PCI. In 
      STEMI, primary PCI is the reperfusion therapy of choice and should be supported 
      by early adjunct treatment with ASA, clopidogrel, UFH and glycoprotein IIb/IIIa 
      inhibitors (abciximab, eptifibatide). "Facilitated" PCI with thrombolytics is not 
      recommended because of increased mortality and complication rates.
FAU - Wichter, T
AU  - Wichter T
AD  - Medizinische Klinik und Poliklinik C (Kardiologie und Angiologie), 
      Universitatsklinikum Munster, Albert-Schweitzer Str. 33, 48149 Munster. 
      wichtet@uni-muenster.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Akutes Koronarsyndrom. Peri-interventionelle antithrombotische Therapie.
PL  - Germany
TA  - Hamostaseologie
JT  - Hamostaseologie
JID - 8204531
RN  - 0 (Antithrombins)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
SB  - IM
MH  - Acute Disease
MH  - Antithrombins/therapeutic use
MH  - Coronary Disease/*drug therapy
MH  - Humans
MH  - Myocardial Infarction/drug therapy/*therapy
MH  - Myocardial Reperfusion
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors
MH  - Syndrome
MH  - *Thrombolytic Therapy
RF  - 60
EDAT- 2006/05/06 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/05/06 09:00
PHST- 2006/05/06 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/05/06 09:00 [entrez]
AID - 06020138 [pii]
PST - ppublish
SO  - Hamostaseologie. 2006 May;26(2):138-46.