PMID- 1667620
OWN - NLM
STAT- MEDLINE
DCOM- 19920623
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 568
IP  - 1-2
DP  - 1991 Dec 24
TI  - Appearance of melatonin receptors during embryonic life in Siberian hamsters 
      (Phodopus sungorous).
PG  - 345-9
AB  - Maternal melatonin readily crosses the placenta to provide the fetus with 
      time-of-day and day length information. To determine if melatonin could have a 
      broader role during development than is currently recognized, melatonin receptor 
      expression was examined in somatic sites during Siberian hamster embryogenesis. 
      Using 125I-labeled-2-iodomelatonin ([125I]MEL), melatonin receptor expression was 
      examined in whole fetuses by in vitro autoradiography. [125I]MEL binding sites 
      were first apparent at gestational day (GD) 10 over the primitive oral pharynx. 
      From GD 12 to 14, binding was present over the nasal pharynx, Rathke's pouch, 
      caudal arteries, and over the thyroid gland during its migration along the 
      thyroglossal duct. By GD 16, Rathke's pouch had differentiated into the pituitary 
      gland, which continued to express specific [125I]MEL binding until birth. From GD 
      16 until birth, binding was no longer detectable over the thyroid gland, but 
      persisted over the nasal epithelium. At all ages, binding sites exhibited high 
      affinity for [125I]MEL and appeared to be coupled with guanosine 
      nucleotide-binding proteins. These data suggest that melatonin receptors are 
      expressed in several somatic sites, including Rathke's pouch and the thyroid 
      gland, during fetal development.
FAU - Rivkees, S A
AU  - Rivkees SA
AD  - Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 
      02114.
FAU - Reppert, S M
AU  - Reppert SM
LA  - eng
GR  - DK-42125/DK/NIDDK NIH HHS/United States
GR  - HD-00924/HD/NICHD NIH HHS/United States
GR  - HD-14427/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Receptors, Melatonin)
RN  - 0 (Receptors, Neurotransmitter)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Cricetinae/*embryology
MH  - Embryonic and Fetal Development
MH  - Gestational Age
MH  - Iodine Radioisotopes
MH  - Melatonin/*metabolism
MH  - Organ Specificity
MH  - Receptors, Melatonin
MH  - Receptors, Neurotransmitter/*metabolism
EDAT- 1991/12/24 00:00
MHDA- 1991/12/24 00:01
CRDT- 1991/12/24 00:00
PHST- 1991/12/24 00:00 [pubmed]
PHST- 1991/12/24 00:01 [medline]
PHST- 1991/12/24 00:00 [entrez]
AID - 0006-8993(91)91424-Y [pii]
AID - 10.1016/0006-8993(91)91424-y [doi]
PST - ppublish
SO  - Brain Res. 1991 Dec 24;568(1-2):345-9. doi: 10.1016/0006-8993(91)91424-y.