PMID- 16678162
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20211122
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 201
IP  - 1
DP  - 2006 Sep
TI  - Correlations between neuronal loss, decrease of memory, and decrease expression 
      of brain-derived neurotrophic factor in the gerbil hippocampus during normal 
      aging.
PG  - 75-83
AB  - It is known that the hippocampus has vital functions in learning and memory, 
      behavioral regulation, and activity-dependent synaptic plasticity, and that the 
      hippocampus contains high levels of brain-derived neurotrophic factor (BDNF). In 
      the present study, we followed age-dependent changes of BDNF immunoreactivity and 
      protein level in the gerbil hippocampus to identify the correlation between BDNF 
      and aging. BDNF immunoreactivity and its protein level significantly increased at 
      postnatal month (PM) 12 in the hippocampus and thereafter reduced. At PM 24, BDNF 
      immunoreactivity in the hippocampal CA1 region and dentate gyrus was similar to 
      that in the PM 1 group, whereas BDNF immunoreactivity in the CA2/3 region at PM 
      24 was higher than that at PM 1. In the PM 24 group, an age-related neuronal loss 
      and the decrease of reference and working memory were observed. In conclusion, 
      our results suggest that observed reduction in BDNF and reference memory may be 
      associated with age-dependent neuronal loss in the hippocampal CA1 region.
FAU - Hwang, In Koo
AU  - Hwang IK
AD  - Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, 
      South Korea.
FAU - Yoo, Ki-Yeon
AU  - Yoo KY
FAU - Jung, Boo-Kyoung
AU  - Jung BK
FAU - Cho, Jun Hwi
AU  - Cho JH
FAU - Kim, Do-Hoon
AU  - Kim DH
FAU - Kang, Tae-Cheon
AU  - Kang TC
FAU - Kwon, Young-Guen
AU  - Kwon YG
FAU - Kim, Yong-Sun
AU  - Kim YS
FAU - Won, Moo Ho
AU  - Won MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060505
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Cell Count
MH  - Dentate Gyrus/cytology/metabolism
MH  - Gerbillinae
MH  - Hippocampus/cytology/*metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - Neurons/cytology/*metabolism
EDAT- 2006/05/09 09:00
MHDA- 2006/11/15 09:00
CRDT- 2006/05/09 09:00
PHST- 2005/12/09 00:00 [received]
PHST- 2006/02/19 00:00 [revised]
PHST- 2006/02/21 00:00 [accepted]
PHST- 2006/05/09 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2006/05/09 09:00 [entrez]
AID - S0014-4886(06)00211-1 [pii]
AID - 10.1016/j.expneurol.2006.02.129 [doi]
PST - ppublish
SO  - Exp Neurol. 2006 Sep;201(1):75-83. doi: 10.1016/j.expneurol.2006.02.129. Epub 
      2006 May 5.