PMID- 16678482
OWN - NLM
STAT- MEDLINE
DCOM- 20060824
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 117
IP  - 6
DP  - 2006 Jun
TI  - Bilateral impairment of intracortical inhibition in delayed-onset posthemiplegic 
      dystonia: pathophysiological implications.
PG  - 1312-8
AB  - OBJECTIVE: To study short interval intracortical inhibition (SICI) in a rare 
      patient with segmental dystonia of the left upper limb due to a vascular lesion 
      in the contralateral putamen without corticospinal tract involvement. METHODS: 
      Paired-pulse transcranial magnetic stimulation (TMS) was applied to both 
      hemispheres in a conditioning-test paradigm. Six interstimulus intervals (ISIs) 
      and 4 conditioning stimulation intensities were investigated in two separate 
      sessions. RESULTS: Motor evoked potentials upon single-pulse TMS were within the 
      normal range, whereas paired-pulse TMS revealed major changes in cortical 
      excitability, proving that SICI was bilaterally absent. CONCLUSIONS: The 
      bilateral impairment of SICI cannot be considered the cause of dystonic 
      contractions, but just a predisposing factor. SIGNIFICANCE: The absence of SICI 
      might be regarded as a condition able to promote maladaptive plastic changes 
      triggered by focal lesions in the putamen.
FAU - Trompetto, Carlo
AU  - Trompetto C
AD  - Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via 
      de Toni, 5, 16132 Genova, Italy.
FAU - Buccolieri, Alessandro
AU  - Buccolieri A
FAU - Bove, Marco
AU  - Bove M
FAU - Brichetto, Gianpaolo
AU  - Brichetto G
FAU - Avanzino, Laura
AU  - Avanzino L
FAU - Marinelli, Lucio
AU  - Marinelli L
FAU - Abbruzzese, Giovanni
AU  - Abbruzzese G
LA  - eng
PT  - Journal Article
DEP - 20060505
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Arm
MH  - Cerebral Cortex/physiology/*physiopathology
MH  - Dystonic Disorders/pathology/*physiopathology
MH  - Electromyography
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - *Functional Laterality
MH  - Hemiplegia/pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neural Inhibition/*physiology
MH  - Neuronal Plasticity/physiology
MH  - Putamen/pathology/*physiopathology
MH  - Pyramidal Tracts/physiology
MH  - Transcranial Magnetic Stimulation
EDAT- 2006/05/09 09:00
MHDA- 2006/08/25 09:00
CRDT- 2006/05/09 09:00
PHST- 2005/12/09 00:00 [received]
PHST- 2006/03/09 00:00 [revised]
PHST- 2006/03/17 00:00 [accepted]
PHST- 2006/05/09 09:00 [pubmed]
PHST- 2006/08/25 09:00 [medline]
PHST- 2006/05/09 09:00 [entrez]
AID - S1388-2457(06)00146-5 [pii]
AID - 10.1016/j.clinph.2006.03.015 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2006 Jun;117(6):1312-8. doi: 10.1016/j.clinph.2006.03.015. 
      Epub 2006 May 5.