PMID- 16678775
OWN - NLM
STAT- MEDLINE
DCOM- 20060612
LR  - 20190613
IS  - 1534-5807 (Print)
IS  - 1534-5807 (Linking)
VI  - 10
IP  - 5
DP  - 2006 May
TI  - Drosophila decapping protein 1, dDcp1, is a component of the oskar mRNP complex 
      and directs its posterior localization in the oocyte.
PG  - 601-13
AB  - In Drosophila, posterior deposition of oskar (osk) mRNA in oocytes is critical 
      for both pole cell and abdomen formation. Exon junction complex components, 
      translational regulation factors, and other proteins form an RNP complex that is 
      essential for directing osk mRNA to the posterior of the oocyte. Until now, it 
      has not been clear whether the mRNA degradation machinery is involved in 
      regulating osk mRNA deposition. Here we show that Drosophila decapping protein 1, 
      dDcp1, is a posterior group gene required for the transport of osk mRNA. In 
      oocytes, dDcp1 is localized posteriorly in an osk mRNA position- and 
      dosage-dependent manner. In nurse cells, dDcp1 colocalizes with dDcp2 and Me31B 
      in discrete foci that may be related to processing bodies (P bodies), which are 
      sites of active mRNA degradation. Thus, as well as being a general factor 
      required for mRNA decay, dDcp1 is an essential component of the osk mRNP 
      localization complex.
FAU - Lin, Ming-Der
AU  - Lin MD
AD  - Institute of Molecular and Cellular Biology, College of Life Science, National 
      Taiwan University, Number 1, Section 4, Roosevelt Road, Taipei, 10617, Taiwan.
FAU - Fan, Shih-Jung
AU  - Fan SJ
FAU - Hsu, Wei-Shan
AU  - Hsu WS
FAU - Chou, Tze-Bin
AU  - Chou TB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Egg Proteins)
RN  - 0 (Lcp2 protein, Drosophila)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (Transcription Factors)
RN  - 0 (YPS protein, Drosophila)
RN  - 0 (chb protein, Drosophila)
RN  - 0 (exu protein, Drosophila)
RN  - 0 (messenger ribonucleoprotein)
RN  - 0 (osk protein, Drosophila)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (Dcp-1 protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Caspases
MH  - Cytoplasm/metabolism
MH  - DNA-Binding Proteins/metabolism
MH  - Drosophila Proteins/*genetics/*metabolism
MH  - Drosophila melanogaster/cytology/*metabolism
MH  - Egg Proteins/metabolism
MH  - Genes, Insect/genetics
MH  - Microtubule-Associated Proteins/metabolism
MH  - Microtubules/metabolism
MH  - Molecular Sequence Data
MH  - Oocytes/*metabolism
MH  - Protein Transport
MH  - RNA Stability
MH  - RNA, Messenger/metabolism
MH  - RNA-Binding Proteins/metabolism
MH  - Ribonucleoproteins/chemistry/*metabolism
MH  - Sequence Alignment
MH  - Transcription Factors/metabolism
EDAT- 2006/05/09 09:00
MHDA- 2006/06/13 09:00
CRDT- 2006/05/09 09:00
PHST- 2005/10/29 00:00 [received]
PHST- 2006/02/04 00:00 [revised]
PHST- 2006/02/28 00:00 [accepted]
PHST- 2006/05/09 09:00 [pubmed]
PHST- 2006/06/13 09:00 [medline]
PHST- 2006/05/09 09:00 [entrez]
AID - S1534-5807(06)00126-2 [pii]
AID - 10.1016/j.devcel.2006.02.021 [doi]
PST - ppublish
SO  - Dev Cell. 2006 May;10(5):601-13. doi: 10.1016/j.devcel.2006.02.021.