PMID- 16679021
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20240109
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 31
IP  - 6
DP  - 2006 Jun
TI  - Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.
PG  - 342-8
AB  - Recent studies are beginning to disclose a signaling network involved in 
      regulating cell size. Although many links and effectors are still unknown, 
      central components of this network include the mammalian target of rapamycin 
      (mTOR) and its downstream effectors - the ribosomal protein S6 kinase (S6K) and 
      the translational repressor eukaryotic initiation factor 4E-binding protein. 
      Until recently, the role of S6K and its many substrates in cell-size control 
      remained obscure; however, a knockin mouse carrying mutations at all 
      phosphorylation sites in the primary S6K substrate, ribosomal protein S6 (rpS6), 
      has provided insight into the physiological role of this protein phosphorylation 
      event. In addition to its role in glucose homeostasis in the whole mouse, 
      phosphorylation of rpS6 is essential for regulating the size of at least some 
      cell types, but is dispensable for translational control of mRNAs with a 5' 
      terminal oligopyrimidine tract (TOP mRNAs) - its previously assigned targets. It 
      therefore seems that establishing the function of the phosphorylation of other 
      effectors of mTOR or S6K will inevitably require genetic manipulation of the 
      respective sites within these targets.
FAU - Ruvinsky, Igor
AU  - Ruvinsky I
AD  - Department of Biochemistry, The Hebrew University-Hadassah Medical School, 
      Jerusalem 91120, Israel.
FAU - Meyuhas, Oded
AU  - Meyuhas O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060506
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (5' Untranslated Regions)
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - 0 (Ribosomal Protein S6)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - 5' Untranslated Regions
MH  - Animals
MH  - *Cell Size
MH  - Eukaryotic Initiation Factor-4E/metabolism
MH  - Humans
MH  - Mice
MH  - Phosphorylation
MH  - Protein Biosynthesis/*physiology
MH  - Protein Kinases/metabolism
MH  - Protein Processing, Post-Translational/*physiology
MH  - Ribosomal Protein S6/*metabolism
MH  - Ribosomal Protein S6 Kinases/metabolism
MH  - TOR Serine-Threonine Kinases
RF  - 49
EDAT- 2006/05/09 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/05/09 09:00
PHST- 2006/01/19 00:00 [received]
PHST- 2006/03/14 00:00 [revised]
PHST- 2006/04/21 00:00 [accepted]
PHST- 2006/05/09 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/05/09 09:00 [entrez]
AID - S0968-0004(06)00113-7 [pii]
AID - 10.1016/j.tibs.2006.04.003 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2006 Jun;31(6):342-8. doi: 10.1016/j.tibs.2006.04.003. Epub 
      2006 May 6.