PMID- 16679060
OWN - NLM
STAT- MEDLINE
DCOM- 20061204
LR  - 20070621
IS  - 1438-4639 (Print)
IS  - 1438-4639 (Linking)
VI  - 209
IP  - 4
DP  - 2006 Jul
TI  - Surveillance of cystic fibrosis patients with multi-drug resistant Gram-negative 
      rods.
PG  - 333-6
AB  - OBJECTIVES: Although several nosocomial outbreaks with multi-drug resistant 
      Gram-negative bacteria (MRGN) are documented, only few are known about the 
      endemic situation of theses pathogens. Especially cystic fibrosis (CF) patients 
      are known to be at risk for MRGN acquisition. We present surveillance data of 
      endemic MRGN in CF patients from a German university hospital during a 3-year 
      period. METHODS: CF inpatients from 2002 to 2004 were included. A MRGN was 
      defined as a Gram-negative rod of which less than two groups of antibiotics had 
      been tested susceptible. MRGN patients who were admitted more than once were 
      counted each time as a new MRGN case. RESULTS: Three hundred and thirty-nine 
      inpatient cases (109 different patients) with MRGN were enrolled. Two hundred and 
      sixty-seven cases were known to be MRGN positive at the time point of admission, 
      167 cases were affected by pan-resistant pathogens. P. aeruginosa was the MRGN 
      species detected most frequently. MRGN was detected after 48h of hospital stay in 
      9 patients. CONCLUSIONS: MRGN surveillance is recommended by several experts but 
      unfortunately only few data has been published. To our knowledge this is the 
      first description of the complete endemic MRGN situation in CF patients. MRGN 
      surveillance is necessary and will be continued in our facility.
FAU - Vonberg, Ralf-Peter
AU  - Vonberg RP
AD  - Institute for Medical Microbiology and Hospital Epidemiology, Medical School 
      Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. 
      Vonberg.Ralf@MH-Hannover.DE
FAU - Wolter, Anneke
AU  - Wolter A
FAU - Ziesing, Stefan
AU  - Ziesing S
FAU - Gastmeier, Petra
AU  - Gastmeier P
LA  - eng
PT  - Journal Article
DEP - 20060506
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-Bacterial Agents/pharmacology
MH  - Child
MH  - Child, Preschool
MH  - Cross Infection/complications/epidemiology/*microbiology
MH  - Cystic Fibrosis/complications/epidemiology/*microbiology
MH  - *Drug Resistance, Multiple, Bacterial
MH  - Female
MH  - Germany
MH  - Gram-Negative Bacteria/drug effects/isolation & purification
MH  - Gram-Negative Bacterial Infections/complications/epidemiology/*microbiology
MH  - Hospitals, University
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
EDAT- 2006/05/09 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/05/09 09:00
PHST- 2005/11/20 00:00 [received]
PHST- 2006/02/22 00:00 [revised]
PHST- 2006/03/12 00:00 [accepted]
PHST- 2006/05/09 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/05/09 09:00 [entrez]
AID - S1438-4639(06)00023-X [pii]
AID - 10.1016/j.ijheh.2006.03.001 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2006 Jul;209(4):333-6. doi: 
      10.1016/j.ijheh.2006.03.001. Epub 2006 May 6.