PMID- 16679092
OWN - NLM
STAT- MEDLINE
DCOM- 20060623
LR  - 20220321
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 97
IP  - 10
DP  - 2006 May 15
TI  - Utility of plasma N-terminal brain natriuretic peptide as a marker of functional 
      capacity in patients with chronic severe mitral regurgitation.
PG  - 1498-501
AB  - Plasma levels of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) are 
      elevated in severe mitral regurgitation, but their relation to functional 
      capacity and cardiac remodeling is not well defined. We evaluated the role of 
      NT-pro-BNP as a marker of functional capacity, symptoms, and cardiac remodeling 
      in 38 patients with severe degenerative mitral regurgitation and preserved left 
      ventricular ejection fraction. The NT-pro-BNP levels increased progressively with 
      New York Heart Association (NYHA) functional class: NYHA class I (geometric mean 
      [GM] 97.1 pg/ml), NYHA class II (GM 169.8 pg/ml), and NYHA III (GM 457.6 pg/ml; p 
      = 0.015). The end-systolic volume index (r = 0.52, p = 0.001), end-diastolic 
      volume index (r = 0.46, p = 0.003), left atrial volume index (r = 0.4, p = 0.01), 
      regurgitant volume index (r = 0.38, p = 0.02), regurgitant fraction (r = 0.46, p 
      = 0.003), and end-diastolic sphericity index (r = 0.56, p <0.001) all correlated 
      significantly with NT-pro-BNP. The NT-pro-BNP levels correlated significantly 
      with the exercise parameters: maximum oxygen uptake (r = -0.6, p <0.001), 
      exercise time (r = -0.52, p <0.001), and oxygen pulse (r = -0.57, p <0.001). In 
      contrast, only weak correlations were obtained between the exercise and 
      echocardiographic variables. NT-pro-BNP was a strong independent predictor of 
      maximum oxygen uptake (p = 0.001). In conclusion, the results of this study have 
      demonstrated that NT-pro-BNP increases progressively with worsening symptoms, is 
      linked to the extent of LV remodeling, and is an independent predictor of 
      functional capacity. NT-pro-BNP may have a role in the optimal treatment of 
      patients with severe mitral regurgitation.
FAU - Yusoff, Rahal
AU  - Yusoff R
AD  - Department of Cardiology, South Manchester University Hospitals, Wythenshawe, 
      Manchester, United Kingdom. ryusoff72@yahoo.com
FAU - Clayton, Nigel
AU  - Clayton N
FAU - Keevil, Brian
AU  - Keevil B
FAU - Morris, Julie
AU  - Morris J
FAU - Ray, Simon
AU  - Ray S
LA  - eng
PT  - Journal Article
DEP - 20060329
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Analysis of Variance
MH  - Biomarkers/*blood
MH  - Chronic Disease
MH  - Echocardiography
MH  - Electrocardiography
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/*blood/diagnostic imaging
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
EDAT- 2006/05/09 09:00
MHDA- 2006/06/24 09:00
CRDT- 2006/05/09 09:00
PHST- 2005/07/21 00:00 [received]
PHST- 2005/11/23 00:00 [revised]
PHST- 2005/11/23 00:00 [accepted]
PHST- 2006/05/09 09:00 [pubmed]
PHST- 2006/06/24 09:00 [medline]
PHST- 2006/05/09 09:00 [entrez]
AID - S0002-9149(06)00289-X [pii]
AID - 10.1016/j.amjcard.2005.11.085 [doi]
PST - ppublish
SO  - Am J Cardiol. 2006 May 15;97(10):1498-501. doi: 10.1016/j.amjcard.2005.11.085. 
      Epub 2006 Mar 29.