PMID- 16679925
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20111006
IS  - 1077-4114 (Print)
IS  - 1077-4114 (Linking)
VI  - 28
IP  - 4
DP  - 2006 Apr
TI  - Successful report of reduced-intensity stem cell transplantation from unrelated 
      umbilical cord blood in a girl with chronic active Epstein-Barr virus infection.
PG  - 254-6
AB  - We describe an 8-year-old girl with chronic active Epstein-Barr virus (EBV) 
      infection (CAEBV) who was treated successfully by reduced-intensity stem cell 
      transplantation (RIST) from unrelated cord blood (CB). She had been suffering 
      from fever, abdominal pain, and interstitial lymphadenopathy, and CAEBV was 
      diagnosed. After chemotherapy that included etoposide, the amount of EBV 
      decreased transiently below the detection level. However, the disease due to 
      CAEBV worsened despite the chemotherapy, and she finally needed chemotherapy 
      every week. Therefore, instead of conventional myeloablative transplantation, we 
      performed CB transplantation with reduced-intensity conditioning regimens 
      consisting of low-dose total body irradiation, fludarabine, and etoposide. CB, 
      for which human leukocyte antigen (HLA) was 2-loci mismatched on the DR loci from 
      an unrelated donor, was infused after conditioning. Although grade III acute 
      graft-versus-host disease (GVHD) in the gut and chronic GVHD in the lung 
      developed, the symptoms of GVHD disappeared with immunosuppressive therapy. After 
      15 months, the patient remained a complete chimera, with undetectable levels of 
      EBV in peripheral blood and bone marrow. We conclude that RIST from unrelated CB 
      can be indicated for some cases of CAEBV who are refractory to chemotherapy and 
      have no HLA-matched related and unrelated donors as the source of bone marrow or 
      peripheral blood stem cells.
FAU - Iguchi, Akihiro
AU  - Iguchi A
AD  - Department of Pediatrics, Hokkaido University School of Medicine, N15 W7 kita-ku, 
      Sapporo City 060-8638, Japan. igurin@med.hokudai.ac.jp
FAU - Kobayashi, Ryoji
AU  - Kobayashi R
FAU - Sato, Tomonobu Z
AU  - Sato TZ
FAU - Nakajima, Masahide
AU  - Nakajima M
FAU - Kaneda, Makoto
AU  - Kaneda M
FAU - Ariga, Tadashi
AU  - Ariga T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - *Blood Transfusion
MH  - Bone Marrow/virology
MH  - Child
MH  - Epstein-Barr Virus Infections/blood/*therapy
MH  - Female
MH  - *Fetal Blood
MH  - Herpesvirus 4, Human/isolation & purification
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Stem Cell Transplantation/*methods
MH  - Transplantation Chimera
MH  - Treatment Outcome
EDAT- 2006/05/09 09:00
MHDA- 2006/06/14 09:00
CRDT- 2006/05/09 09:00
PHST- 2006/05/09 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/05/09 09:00 [entrez]
AID - 00043426-200604000-00012 [pii]
AID - 10.1097/01.mph.0000212916.29889.c2 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2006 Apr;28(4):254-6. doi: 
      10.1097/01.mph.0000212916.29889.c2.