PMID- 16680163
OWN - NLM
STAT- MEDLINE
DCOM- 20060811
LR  - 20220408
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 9
IP  - 6
DP  - 2006 Jun
TI  - BDNF val66met polymorphism is associated with modified experience-dependent 
      plasticity in human motor cortex.
PG  - 735-7
AB  - Motor training can induce profound physiological plasticity within primary motor 
      cortex, including changes in corticospinal output and motor map topography. Using 
      transcranial magnetic stimulation, we show that training-dependent increases in 
      the amplitude of motor-evoked potentials and motor map reorganization are reduced 
      in healthy subjects with a val66met polymorphism in the brain-derived 
      neurotrophic factor gene (BDNF), as compared to subjects without the 
      polymorphism. The results suggest that BDNF is involved in mediating 
      experience-dependent plasticity of human motor cortex.
FAU - Kleim, Jeffrey A
AU  - Kleim JA
AD  - Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer 
      Road, Gainesville, Florida 32608, USA. jkleim@ufl.edu
FAU - Chan, Sheila
AU  - Chan S
FAU - Pringle, Erin
AU  - Pringle E
FAU - Schallert, Kellan
AU  - Schallert K
FAU - Procaccio, Vincent
AU  - Procaccio V
FAU - Jimenez, Richard
AU  - Jimenez R
FAU - Cramer, Steven C
AU  - Cramer SC
LA  - eng
GR  - 5M01RR 00827-29/RR/NCRR NIH HHS/United States
GR  - NS-45563/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20060507
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution/*genetics
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Evoked Potentials, Motor/genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Learning/physiology
MH  - Male
MH  - Methionine/genetics
MH  - Motor Cortex/anatomy & histology/*physiology
MH  - Motor Skills/*physiology
MH  - Movement/physiology
MH  - Nerve Regeneration/genetics
MH  - Neuronal Plasticity/*genetics
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic/*genetics
MH  - Recovery of Function/genetics
MH  - Transcranial Magnetic Stimulation
MH  - Valine/genetics
EDAT- 2006/05/09 09:00
MHDA- 2006/08/12 09:00
CRDT- 2006/05/09 09:00
PHST- 2006/01/17 00:00 [received]
PHST- 2006/04/17 00:00 [accepted]
PHST- 2006/05/09 09:00 [pubmed]
PHST- 2006/08/12 09:00 [medline]
PHST- 2006/05/09 09:00 [entrez]
AID - nn1699 [pii]
AID - 10.1038/nn1699 [doi]
PST - ppublish
SO  - Nat Neurosci. 2006 Jun;9(6):735-7. doi: 10.1038/nn1699. Epub 2006 May 7.