PMID- 16681438
OWN - NLM
STAT- MEDLINE
DCOM- 20060814
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 44
IP  - 5
DP  - 2006
TI  - Cut-off values for total serum immunoglobulin E between non-atopic and atopic 
      children in north-west Croatia.
PG  - 639-47
AB  - BACKGROUND: The aim of this study was to determine cut-off values for total serum 
      immunoglobulin E (IgE) between non-atopic and atopic children with respiratory 
      symptoms. Children of 0-16 years of age were evaluated for respiratory symptoms 
      of >4-week duration. METHODS: Children were divided into two groups: non-atopic 
      children (n=3355) who were non-IgE-sensitized with undetectable allergen-specific 
      IgE (<0.35 kIU(A)/L), and atopic children (n=4620) who were sensitized to > or =1 
      allergens (specific IgE > or =0.35 kIU(A)/L). Upper and lower centiles were 
      determined and cut-off values calculated using receiver operating characteristic 
      (ROC) analysis. RESULTS: Serum total IgE increased with age in both groups, 
      although at a variable level and rate, and reached a plateau at 9 and 10 years in 
      non-atopic and atopic children, respectively. Atopic children had on average 
      14-fold higher serum total IgE compared to non-atopic children. In both groups, 
      the median was lower than the corresponding mean and the distribution skewness 
      was always positive (group I, 0.87; group II, 0.91). In almost all age groups, 
      the 95th percentile for non-atopic children corresponded to the calculated 
      cut-off values, whereas the 10th percentile for atopic children corresponded to 
      the respective cut-off values only until the age of 8 years, after which greater 
      differences between the cut-off values and the 10th percentile were recorded. 
      Cut-off values for total serum IgE in children up to 16 years were determined 
      with diagnostic sensitivity, specificity and area under the ROC curve of 96%, 91% 
      and 0.950, respectively. CONCLUSIONS: The 95th percentile for total IgE in 
      non-atopic children and the 10th percentile in atopic children could be taken as 
      cut-off values in children up to 8 years of age, after which significant 
      percentile discrepancies between non-atopic and atopic children were recorded. 
      Since atopic subjects show a more irregular centile distribution, cut-off values 
      are best determined by ROC analysis.
FAU - Dodig, Slavica
AU  - Dodig S
AD  - National Reference Center for Pediatric Allergy, Pediatric Hospital Srebrnjak, 
      Srebrnjak 100, 10000 Zagreb, Croatia. slavica.dodig@zg.t-com.hr
FAU - Richter, Darko
AU  - Richter D
FAU - Benko, Bojan
AU  - Benko B
FAU - Zivcic, Jadranka
AU  - Zivcic J
FAU - Raos, Miljenko
AU  - Raos M
FAU - Nogalo, Boro
AU  - Nogalo B
FAU - Cepelak, Ivana
AU  - Cepelak I
FAU - Dodig, Matko
AU  - Dodig M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Chemistry, Clinical/methods
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Croatia
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*blood
MH  - Immunoglobulin E/*biosynthesis/*blood/metabolism
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - ROC Curve
MH  - Reference Values
MH  - Respiratory Tract Diseases/*blood
EDAT- 2006/05/10 09:00
MHDA- 2006/08/15 09:00
CRDT- 2006/05/10 09:00
PHST- 2006/05/10 09:00 [pubmed]
PHST- 2006/08/15 09:00 [medline]
PHST- 2006/05/10 09:00 [entrez]
AID - 10.1515/CCLM.2006.092 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2006;44(5):639-47. doi: 10.1515/CCLM.2006.092.