PMID- 16681560
OWN - NLM
STAT- MEDLINE
DCOM- 20060915
LR  - 20220318
IS  - 0742-3071 (Print)
IS  - 0742-3071 (Linking)
VI  - 23
IP  - 5
DP  - 2006 May
TI  - Mortality in people with type 2 diabetes in the UK.
PG  - 516-21
AB  - AIMS: Under-reporting of diabetes on death certificates contributes to the 
      unreliable estimates of mortality as a result of diabetes. The influence of 
      obesity on mortality in Type 2 diabetes is not well documented. We aimed to study 
      mortality from diabetes and the influence of obesity on mortality in Type 2 
      diabetes in a large cohort selected from the General Practice Research Database 
      (GPRD). Methods A cohort of 44 230 patients aged 35-89 years in 1992 with Type 2 
      diabetes was identified. A comparison group matched by year of birth and sex with 
      no record of diabetes at any time was identified (219 797). Hazards ratios (HRs) 
      for all-cause mortality during the period January 1992 to October 1999 were 
      calculated using the Cox Proportional Hazards Model. The effects of body mass 
      index (BMI), smoking and duration of diabetes on all-cause mortality amongst 
      people with diabetes was assessed (n = 28 725). Results The HR for all-cause 
      mortality in Type 2 diabetes compared with no diabetes was 1.93 (95% CI 
      1.89-1.97), in men 1.77 (1.72-1.83) and in women 2.13 (2.06-2.20). The HR 
      decreased with increasing age. In the multivariate analysis in diabetes only, the 
      HR for all-cause mortality amongst smokers was 1.50 (1.41-1.61). Using BMI 20-24 
      kg/m(2) as the reference range, for those with a BMI 35-54 kg/m(2) the HR was 
      1.43 (1.28-1.59) and for those with a BMI 15-19 kg/m(2) the HR was 1.38 
      (1.18-1.61). CONCLUSIONS: Patients with Type 2 diabetes have almost double the 
      mortality rate compared with those without. The relative risk decreases with age. 
      In people with Type 2 diabetes, obesity and smoking both contribute to the risk 
      of all-cause mortality, supporting doctrines to stop smoking and lose weight.
FAU - Mulnier, H E
AU  - Mulnier HE
AD  - Postgraduate Medical School, University of Surrey, Guildford, UK.
FAU - Seaman, H E
AU  - Seaman HE
FAU - Raleigh, V S
AU  - Raleigh VS
FAU - Soedamah-Muthu, S S
AU  - Soedamah-Muthu SS
FAU - Colhoun, H M
AU  - Colhoun HM
FAU - Lawrenson, R A
AU  - Lawrenson RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/complications/*mortality
MH  - Family Practice
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*mortality
MH  - Odds Ratio
MH  - Risk Factors
MH  - Sex Distribution
MH  - Time Factors
MH  - United Kingdom/epidemiology
EDAT- 2006/05/10 09:00
MHDA- 2006/09/16 09:00
CRDT- 2006/05/10 09:00
PHST- 2006/05/10 09:00 [pubmed]
PHST- 2006/09/16 09:00 [medline]
PHST- 2006/05/10 09:00 [entrez]
AID - DME1838 [pii]
AID - 10.1111/j.1464-5491.2006.01838.x [doi]
PST - ppublish
SO  - Diabet Med. 2006 May;23(5):516-21. doi: 10.1111/j.1464-5491.2006.01838.x.