PMID- 16681924
OWN - NLM
STAT- MEDLINE
DCOM- 20080303
LR  - 20060509
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 86
IP  - 10
DP  - 2006 Mar 14
TI  - [Characteristics of the daily blood glucose profiles of impaired glucose 
      tolerance and type 2 diabetes mellitus subjects by continuous glucose monitoring 
      system].
PG  - 674-7
AB  - OBJECTIVE: To investigate the characteristics of daily glucose profiles of the 
      impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) subjects by 
      continuous glucose monitoring system (CGMS) so as to instruct the development of 
      rational programs of treatment. METHODS: The CGMS data of 6 normal glucose 
      tolerance (NGT), 10 IGT, and 20 newly diagnosed T2DM subjects were analyzed. 
      RESULTS: (1) The values of average blood glucose, standard deviation of blood 
      glucose, total time of plasma glucose > or = 7.8 mmol/L (T(PG) > or = 7.8 mmol/L) 
      of the T2DM subjects were all significantly higher than those of IGT subjects 
      (all P < 0.05), and these values of the IGI subjects were all significantly 
      higher than those of the NGT subjects (all P < 0.05). The CGMS blood glucose 
      profile excursion were also more and more fluctuant with the deterioration of 
      glucose tolerance. (2) In the IGT group, the time of PG reaching peak was 109 
      minutes +/- 32 minutes and the daily time of PG > or = 7.8 mmol/L was 3.0 hours 
      +/- 0.8 hours. In the newly diagnosed T2DM group, the time of PG reaching peak 
      was 92 minutes +/- 22 minutes, and the daily time of PG > or = 11.1 mmol/L was 
      12.6 hours +/- 1.3 hours. The blood glucose increased more quickly and more 
      sharply, and continued for more time after breakfast. CONCLUSIONS: (1) CGMS data 
      accurately display the characteristics of daily 24 h blood glucose profiles of 
      the IGT and newly diagnosed T2DM subjects, and CGMS examination helps instruct 
      the development of rational treatment program. (2) In daily life, the time of PG 
      > or = 7.8 mmol/L in IGT subjects was nearly 3 hours. (3) With the deterioration 
      of glucose tolerance, the postprandial glucose peak is elevated higher and more 
      rapidly, and the daily blood glucose profile excursion becomes more and more 
      fluctuant.
FAU - Wang, Xian-ling
AU  - Wang XL
AD  - Department of Endocrinology, General Hospital of Chinese People's Liberation 
      Army, Beijing 100853, China.
FAU - Lu, Ju-ming
AU  - Lu JM
FAU - Pan, Chang-yu
AU  - Pan CY
FAU - Mu, Yi-ming
AU  - Mu YM
FAU - Dou, Jing-tao
AU  - Dou JT
FAU - Ba, Jian-ming
AU  - Ba JM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Time Factors
EDAT- 2006/05/10 09:00
MHDA- 2008/03/04 09:00
CRDT- 2006/05/10 09:00
PHST- 2006/05/10 09:00 [pubmed]
PHST- 2008/03/04 09:00 [medline]
PHST- 2006/05/10 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2006 Mar 14;86(10):674-7.