PMID- 16682284
OWN - NLM
STAT- MEDLINE
DCOM- 20060612
LR  - 20101118
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 167
IP  - 1
DP  - 2006 May
TI  - Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by 
      fluorescence in situ hybridization in essential thrombocythemia.
PG  - 39-42
AB  - No specific diagnostic markers have been described in essential thrombocythemia 
      (ET). PRV-1 (polycythemia rubra vera-1), TPO (thrombopoietin), and c-MPL 
      (myeloproliferative leukemia virus oncogene) genes are candidate ET molecular 
      markers because of their implication in the pathogenesis of ET. We have studied 
      the status of PRV-1, TPO, and c-MPL genes in 30 ET patients by a fluorescence in 
      situ hybridization (FISH) technique using three noncommercial, locus-specific 
      probes for PRV-1 (BAC RP11-160A19, located at 19q13.2), TPO (BAC RP11-45NP16, 
      located at 3q27), and c-MPL (BAC RP11-297L5, located at 1p34). FISH study showed 
      no PRV-1, TPO, and c-MPL cytogenetic abnormalities in any of the analyzed cases. 
      Our results suggest a lack of structural and numerical rearrangements (deletions, 
      translocations, or amplifications) of PRV-1, TPO, and c-MPL genes in ET patients.
FAU - Puigdecanet, Eulalia
AU  - Puigdecanet E
AD  - Laboratori de Citogenetica i Biologia Molecular, Servei de Patologia, Hospital 
      del Mar, Barcelona, Spain. eulalia.puigdecanet01@campus.upf.es
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Villa, Olaya
AU  - Villa O
FAU - Florensa, Lourdes
AU  - Florensa L
FAU - Besses, Carles
AU  - Besses C
FAU - Serrano, Sergi
AU  - Serrano S
FAU - Sole, Francesc
AU  - Sole F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Autoantigens)
RN  - 0 (CD177 protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Iron-Binding Proteins)
RN  - 0 (Isoantigens)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, Thrombopoietin)
RN  - 143641-95-6 (MPL protein, human)
RN  - EC 1.11.1.7 (TPO protein, human)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
SB  - IM
MH  - Autoantigens/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - GPI-Linked Proteins
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Iodide Peroxidase/*genetics
MH  - Iron-Binding Proteins/*genetics
MH  - Isoantigens/*genetics
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Proto-Oncogene Proteins/*genetics
MH  - Receptors, Cell Surface/*genetics
MH  - Receptors, Cytokine/*genetics
MH  - Receptors, Thrombopoietin
MH  - Thrombocythemia, Essential/*genetics
EDAT- 2006/05/10 09:00
MHDA- 2006/06/13 09:00
CRDT- 2006/05/10 09:00
PHST- 2005/04/29 00:00 [received]
PHST- 2005/08/08 00:00 [revised]
PHST- 2005/08/16 00:00 [accepted]
PHST- 2006/05/10 09:00 [pubmed]
PHST- 2006/06/13 09:00 [medline]
PHST- 2006/05/10 09:00 [entrez]
AID - S0165-4608(05)00497-8 [pii]
AID - 10.1016/j.cancergencyto.2005.08.016 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 May;167(1):39-42. doi: 
      10.1016/j.cancergencyto.2005.08.016.